Trimela Cream 0.01% + 4% + 0.05% is a triple-combination topical formulation specially designed for the short-term treatment of moderate to severe facial melasma. It works by reducing hyperpigmentation, improving skin tone, and controlling inflammation associated with melasma. To achieve optimal results and minimize adverse effects, strict sun protection is essential during therapy.

Indications

• Short-term treatment of moderate to severe melasma of the face

• Patients should avoid sun exposure during treatment

• Daily use of a broad-spectrum sunscreen with SPF 30 or higher is mandatory

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Pharmacology

Trimela Cream combines three proven dermatological agents:

• Fluocinolone Acetonide (0.01%)
  A topical corticosteroid with anti-inflammatory properties that helps reduce redness and irritation.

• Hydroquinone (4%)
  A depigmenting agent that inhibits melanin production by interfering with the tyrosine–tyrosinase pathway.

• Tretinoin (0.05%)
  A keratolytic agent that promotes skin cell turnover, enhances penetration of hydroquinone, and improves pigment dispersion.

Although the exact mechanism in melasma is not fully understood, the combined action effectively reduces hyperpigmentation.

Dosage and Administration

• Apply once daily at night, at least 30 minutes before bedtime

• Cleanse face and neck gently, rinse, and pat dry

• Apply a thin layer to affected areas, extending about ½ inch onto surrounding normal skin

• Rub gently and evenly

• Use sunscreen and protective clothing during the day

• Moisturizers and cosmetics may be used during daytime

Pediatric Use:
Safety and efficacy in pediatric patients have not been established.

Drug Interactions

Avoid concurrent use of:

• Medicated or abrasive soaps and cleansers

• Cosmetics with strong drying effects

• Products containing high alcohol concentrations or astringents

• Other irritants or keratolytic agents

• Medications with photosensitizing effects

Contraindications

• Known hypersensitivity, allergy, or intolerance to any component of Trimela Cream

Side Effects

• Mild to moderate redness, peeling, burning, dryness, or itching

• Rarely, severe allergic reactions including breathing difficulty or asthma exacerbation

Pregnancy and Lactation

Pregnancy:
Pregnancy Category C. Trimela Cream contains tretinoin, a known teratogen. Animal studies suggest potential risks such as fetal death, growth alterations, and congenital malformations. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Lactation:
It is unknown whether topical application results in sufficient systemic absorption to be excreted in breast milk. Caution is advised when administering to nursing mothers.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Hydroquinone and tretinoin may cause local skin irritation such as redness, peeling, burning, dryness, or itching

• Discontinue use if severe irritation or hypersensitivity occurs

• Fluocinolone Acetonide may cause reversible HPA axis suppression with prolonged or excessive use

• Signs of systemic corticosteroid absorption include Cushing’s syndrome, hyperglycemia, and glucosuria

• Discontinue treatment if HPA axis suppression is detected; recovery usually occurs after stopping therapy

Therapeutic Class

• Hydroquinone Preparations

Storage Conditions

• Store in a cool and dry place, protected from light

• Do not freeze

• Keep out of reach of children.