Indications

Tridosil 500 mg/vial is a macrolide antibiotic indicated for the treatment of a wide range of bacterial infections caused by susceptible organisms. It is commonly prescribed for:

• Upper respiratory tract infections such as sinusitis and pharyngitis/tonsillitis

• Lower respiratory tract infections including bronchitis and pneumonia

• Otitis media

• Skin and soft tissue infections

• Sexually transmitted infections, particularly non-gonococcal urethritis and cervicitis caused by Chlamydia trachomatis in both men and women

Therapeutic Class

Macrolide Antibiotic

Pharmacology

Tridosil 500 mg/vial belongs to the azalide subclass of macrolide antibiotics. It works by binding to the 50S ribosomal subunit of susceptible microorganisms, thereby inhibiting bacterial protein synthesis and preventing bacterial growth.

It is active against a broad spectrum of gram-positive and gram-negative bacteria, as well as certain anaerobes and atypical pathogens. These include Staphylococcus aureus, Streptococcus species, Escherichia coli, Moraxella catarrhalis, Bacteroides fragilis, Bordetella pertussis, Neisseria gonorrhoeae, and Haemophilus ducreyi. In vitro studies have also demonstrated activity against Mycoplasma pneumoniae, Legionella pneumophila, Campylobacter species, Treponema pallidum, Toxoplasma gondii, and Borrelia burgdorferi.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Dosage

Adults:

• 500 mg once daily for 3 days
  or

• 500 mg on day 1, followed by 250 mg once daily on days 2–5

For sexually transmitted infections caused by Chlamydia trachomatis:

• A single dose of 1 g
  or

• 500 mg on day 1, followed by 250 mg once daily for the next 2 days

Children (over 6 months):

• 10 mg/kg body weight once daily for 3 days

Weight-based dosing guidance:

• 15–25 kg: 200 mg once daily for 3 days

• 26–35 kg: 300 mg once daily for 3 days

• 36–45 kg: 400 mg once daily for 3 days

Typhoid Fever:

• 500 mg once daily for 7–10 days

Dosage should be adjusted as directed by a physician.

Administration

For reconstitution of the suspension:

1. Shake the bottle thoroughly to loosen the powder.

2. Add boiled and cooled water up to the marked level on the bottle label.

3. Shake well until the powder is completely mixed.

Tridosil 500 mg/vial should be taken at least one hour before or two hours after meals.

Drug Interactions

• Food and antacids may reduce the absorption of Tridosil 500 mg/vial.

• Concomitant use with ergot alkaloids should be avoided due to the risk of ergotism.

• Caution is advised when used with cyclosporin or digoxin, as macrolides may increase their plasma levels.

• No significant interactions have been reported with warfarin, theophylline, carbamazepine, methylprednisolone, or cimetidine.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

• Known hypersensitivity to Tridosil 500 mg/vial or other macrolide antibiotics

• Concomitant use with ergot derivatives

• Patients with existing liver disorders

Side Effects

Tridosil 500 mg/vial is generally well tolerated. Reported side effects are usually mild and reversible upon discontinuation and may include:

• Nausea and vomiting

• Abdominal pain or cramps

• Diarrhea and flatulence

• Headache

• Skin rash

Pregnancy & Lactation

Tridosil 500 mg/vial is classified as Pregnancy Category B. Animal studies have not shown fetal harm, but adequate and well-controlled studies in pregnant women are lacking. It should be used during pregnancy only if clearly needed.

It is not known whether Tridosil 500 mg/vial is excreted in breast milk. Caution should be exercised when prescribing it to nursing mothers.

Precautions & Warnings

• Prolonged use may result in superinfection with non-susceptible organisms, including fungi.

• Patients with renal impairment generally do not require dose adjustment.

• Liver function should be monitored in patients with hepatic conditions.

Overdose

There is limited information regarding overdose with Tridosil 500 mg/vial. Symptoms of macrolide overdose may include severe nausea, vomiting, diarrhea, and reversible hearing impairment. Supportive treatment and gastric lavage may be considered if necessary.

Storage Conditions

Store in a dry place, away from heat and direct light. Keep out of the reach of children.