Traneta M Tablet 2.5 mg + 500 mg is a combination oral antidiabetic medicine used for the management of type 2 diabetes mellitus in adults. It contains Linagliptin (2.5 mg) and Metformin Hydrochloride (500 mg), two complementary agents that work together to improve blood glucose control when diet and exercise alone are not sufficient.

This fixed-dose combination is particularly beneficial for patients who require dual therapy to achieve and maintain optimal glycemic control.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Linagliptin 2.5 mg

• Metformin Hydrochloride 500 mg

Indications

Traneta M Tablet is indicated for:

• Management of type 2 diabetes mellitus in adults

• Improving glycemic control as an adjunct to diet and exercise

• Patients inadequately controlled on metformin alone

• Patients already receiving linagliptin and metformin as separate tablets

Therapeutic Class

• Antidiabetic agents (DPP-4 inhibitor + Biguanide)

Pharmacology

Linagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It works by increasing the levels of incretin hormones, which stimulate insulin release and suppress glucagon secretion in a glucose-dependent manner. This helps lower blood glucose levels without significantly increasing the risk of hypoglycemia.

Metformin Hydrochloride is a biguanide that reduces hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. It is considered the first-line therapy for type 2 diabetes due to its proven efficacy and safety profile.

The combination provides effective blood sugar control through complementary mechanisms of action.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Dosage and Administration

• The dosage should be individualized based on the patient’s glycemic control, tolerability, and prior therapy

• Usually taken once or twice daily with meals to reduce gastrointestinal side effects

• Follow the physician’s instructions carefully

Benefits

• Effective control of fasting and postprandial blood glucose

• Low risk of hypoglycemia when used alone

• Improves insulin sensitivity

• Convenient fixed-dose combination improves patient compliance

Use in Special Populations

• Use with caution in patients with renal impairment

• Not recommended in patients with severe renal dysfunction

• Use during pregnancy and breastfeeding only if clearly needed and prescribed by a physician

Possible Side Effects

Common side effects may include:

• Nausea

• Diarrhea

• Abdominal discomfort

• Headache

Serious but rare side effects may include lactic acidosis (associated with metformin), especially in patients with renal impairment.

Storage

• Store in a cool and dry place

• Protect from light and moisture

• Keep out of reach of children

Precautions

• Regular monitoring of blood glucose and renal function is recommended

• Avoid excessive alcohol intake

• Inform your doctor about any other medications being taken.