Amlodipine Besilate inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. This results in relaxation of peripheral arterioles, reduction of peripheral vascular resistance, and a gradual decrease in blood pressure without significant reflex tachycardia.
Telmisartan selectively blocks the binding of angiotensin II to the AT1 receptor located in vascular smooth muscle and adrenal glands. Angiotensin II normally causes vasoconstriction and aldosterone release, leading to sodium and water retention. By inhibiting these actions, telmisartan promotes vasodilation and reduces blood volume and blood pressure.
The combination of amlodipine and telmisartan provides an additive and complementary antihypertensive effect, achieving better blood pressure control than either agent alone.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Telmacal Tablet 5 mg + 80 mg is indicated for:

• Treatment of essential hypertension in adults

• Patients whose blood pressure is not adequately controlled with amlodipine or telmisartan monotherapy

• Patients requiring high-dose ARB in combination with a calcium channel blocker

Dosage and Administration

• Dosage should be individualized according to patient response and clinical condition

• The usual recommended dose is one tablet once daily

• Tablets may be taken with or without food

• Blood pressure should be monitored regularly during treatment

• Dose adjustment may be necessary in elderly patients or those with hepatic impairment

Contraindications

• Hypersensitivity to amlodipine, telmisartan, or any component of the formulation

• Pregnancy and lactation

• Severe hepatic impairment or biliary obstructive disorders

Warnings and Precautions

• Hypotension may occur, particularly in patients with volume or sodium depletion

• Peripheral edema may occur due to amlodipine

• Use with caution in patients with renal or hepatic impairment

• Avoid concomitant use with other agents acting on the renin-angiotensin system unless clinically indicated

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Common side effects may include:

• Dizziness or headache

• Peripheral edema

• Flushing

• Fatigue

• Hypotension

Most adverse reactions are mild to moderate and tend to resolve with continued therapy or dose adjustment.

Drug Interactions

• Other antihypertensive drugs may enhance the blood pressure-lowering effect

• NSAIDs may reduce antihypertensive efficacy and affect renal function

• Potassium supplements or potassium-sparing diuretics should be used cautiously

Pregnancy and Lactation

• Telmacal Tablet is contraindicated during pregnancy due to the risk of fetal harm

• Breastfeeding should be discontinued during treatment

Storage Conditions

• Store below 30°C in a cool and dry place

• Protect from light and moisture

• Keep out of reach of children

Presentation

Telmacal Tablet 5 mg + 80 mg is available in blister packs, ensuring product stability and convenient once-daily dosing.