Amlodipine Besilate inhibits the influx of calcium ions into vascular smooth muscle and myocardial cells. This results in vasodilation, reduced peripheral vascular resistance, and a gradual lowering of blood pressure. Its long duration of action ensures smooth blood pressure control without significant reflex tachycardia.
Telmisartan selectively blocks the binding of angiotensin II to the AT1 receptor in vascular smooth muscle and adrenal glands. By preventing angiotensin II–mediated vasoconstriction and aldosterone release, telmisartan promotes vasodilation and reduces sodium and water retention.
The combination of amlodipine and telmisartan provides an additive antihypertensive effect, achieving better blood pressure control than either agent alone.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Telmacal Tablet 10 mg + 40 mg is indicated for:

• Treatment of essential hypertension in adults

• Patients whose blood pressure is not adequately controlled with amlodipine or telmisartan alone

• Patients requiring combination therapy for optimal blood pressure management

Dosage and Administration

• Dosage should be individualized based on patient response and clinical condition

• The usual recommended dose is one tablet once daily

• Tablets may be taken with or without food

• Blood pressure should be monitored regularly during therapy

• Dose adjustment may be required in elderly patients or those with hepatic impairment

Contraindications

• Hypersensitivity to amlodipine, telmisartan, or any component of the formulation

• Pregnancy and lactation

• Severe hepatic impairment or biliary obstructive disorders

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Warnings and Precautions

• Hypotension may occur, particularly in volume-depleted patients

• Peripheral edema may occur due to amlodipine

• Use with caution in patients with renal or hepatic impairment

• Avoid concomitant use with other agents acting on the renin-angiotensin system unless clearly indicated

Side Effects

Commonly reported side effects include:

• Dizziness or headache

• Peripheral edema

• Flushing

• Fatigue

• Hypotension

Most adverse effects are mild to moderate and usually resolve with continued treatment or dose adjustment.

Drug Interactions

• Other antihypertensive agents may enhance blood pressure-lowering effects

• NSAIDs may reduce antihypertensive efficacy and impair renal function

• Potassium supplements or potassium-sparing diuretics should be used with caution

Pregnancy and Lactation

• Telmacal Tablet is contraindicated during pregnancy due to the risk of fetal harm

• Breastfeeding is not recommended during therapy

Storage Conditions

• Store below 30°C in a cool and dry place

• Protect from light and moisture

• Keep out of reach of children

Presentation

Telmacal Tablet 10 mg + 40 mg is supplied in blister packs to ensure stability, safety, and convenient once-daily dosing.