Sinjard-M XR Tablet 5 mg+1000 mg is an extended-release combination oral antidiabetic medicine containing Empagliflozin and Metformin Hydrochloride. It is used for the management of type 2 diabetes mellitus in adults when blood glucose levels are not adequately controlled with diet, exercise, or monotherapy. The XR (extended-release) formulation provides sustained drug release, improving glycemic control while enhancing gastrointestinal tolerability.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Empagliflozin 5 mg
• Metformin Hydrochloride 1000 mg (Extended Release)

Mechanism of Action

Sinjard-M XR Tablet works through dual complementary mechanisms:

• Empagliflozin: An SGLT2 inhibitor that reduces glucose reabsorption in the kidneys, increasing urinary glucose excretion and lowering blood sugar levels independently of insulin.
• Metformin Hydrochloride (XR): A biguanide that decreases hepatic glucose production, reduces intestinal glucose absorption, and improves insulin sensitivity in peripheral tissues. The extended-release form ensures gradual drug release for sustained effect and better gastrointestinal tolerance.

Indications

Sinjard-M XR Tablet is indicated for:

• Management of type 2 diabetes mellitus in adults
• Patients inadequately controlled on diet, exercise, or single-drug therapy
• Combination therapy requiring improved and sustained glycemic control

Dosage and Administration

• The dosage should be prescribed by a physician based on individual patient needs.
• Usually taken once daily with meals, preferably in the evening to improve tolerance of Metformin XR.
• Swallow the tablet whole; do not crush or chew.
• Regular monitoring of blood glucose levels is recommended.

Benefits

• Dual-action blood glucose control through two complementary mechanisms
• Extended-release formulation for improved gastrointestinal tolerance
• Helps reduce fasting and postprandial glucose levels
• Supports weight management by promoting glucose excretion
• May offer cardiovascular and renal protective benefits in diabetic patients

Side Effects

Common side effects may include:

• Nausea or mild gastrointestinal discomfort
• Diarrhea or abdominal bloating
• Increased urination
• Urinary tract or genital infections
• Headache

Rare but serious side effects include lactic acidosis (associated with Metformin), ketoacidosis, or severe dehydration. Immediate medical attention is required if severe symptoms occur.

Precautions and Warnings

• Not suitable for patients with type 1 diabetes or diabetic ketoacidosis.
• Use cautiously in patients with renal or hepatic impairment.
• Avoid excessive alcohol intake due to increased risk of lactic acidosis.
• Maintain adequate hydration during treatment.
• Regular monitoring of kidney function and blood glucose is essential.
• Consult a physician if pregnant or breastfeeding.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Sinjard-M XR Tablet may interact with:

• Diuretics (increased risk of dehydration)
• Insulin or other antidiabetic agents (risk of hypoglycemia)
• Alcohol (increased risk of lactic acidosis)
• Certain antihypertensive medications

Always inform your healthcare provider about all current medications.

Storage

• Store below 30°C in a dry place
• Protect from moisture and direct sunlight
• Keep out of reach of children.