Rostil SR 200 mg is a musculotropic antispasmodic formulated as a sustained-release capsule, containing Mebeverine 200 mg. It is designed for the symptomatic management of gastrointestinal disorders associated with abnormal gut motility, particularly Irritable Bowel Syndrome (IBS). The sustained-release (SR) formulation allows for prolonged action, reducing the frequency of dosing and providing consistent relief from abdominal cramps, colicky pain, and discomfort.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Anticholinergics

• Musculotropic Antispasmodics

Indications

Rostil SR 200 mg is indicated for the symptomatic relief of gastrointestinal disorders, including:

• Irritable Bowel Syndrome (IBS)

• Chronic irritable colon

• Spastic constipation

• Mucous colitis

• Colicky abdominal pain

• Persistent non-specific diarrhea

This medication helps relieve abdominal cramps and spasms, improving bowel function and patient comfort.

Pharmacology

Mebeverine, the active ingredient in Rostil SR, is a musculotropic antispasmodic. It works by relaxing the smooth muscles of the gastrointestinal tract without affecting normal gut motility. Unlike some anticholinergics, Mebeverine does not have systemic anticholinergic effects, making it safer with fewer side effects such as dry mouth or blurred vision.

The mechanism of action involves:

• Direct action on intestinal smooth muscles, reducing contractions

• Restoring normal gut motility in cases of functional gastrointestinal disorders

• Alleviating abdominal pain and discomfort associated with IBS and other spastic conditions

The sustained-release formulation ensures that therapeutic levels are maintained throughout the day, reducing the need for frequent dosing.

Dosage & Administration

Adults, elderly, and children over 10 years:

• Mebeverine Tablet 135 mg: 1 tablet three times daily

• Rostil SR 200 mg Capsule: 1 capsule twice daily

Administration Tips:

• Take 20 minutes before meals for maximum efficacy

• After achieving symptom relief, the dose may be gradually reduced

• If a dose is missed, take it as soon as possible unless it is almost time for the next dose; do not double the dose

Pediatric Use:

• Not recommended for children under 10 years

Drug Interactions

• No significant drug interactions have been identified with Mebeverine.

Contraindications

• Hypersensitivity to Mebeverine or any excipients in the formulation

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Rostil SR 200 mg is generally well tolerated. Rare side effects may include:

• Skin rash

• Urticaria

• Angioedema

Precautions & Warnings

• Use with caution in patients with porphyria or a history of allergic reactions

• Monitor patients if symptoms persist or worsen

Overdose

• Overdose may theoretically cause CNS excitability

• No specific antidote exists

• Gastric lavage and supportive symptomatic treatment are recommended

Pregnancy & Lactation

• Animal studies have shown no teratogenic effects

• Use during pregnancy should follow standard precautions

• Mebeverine is not excreted in breast milk at therapeutic doses

Storage

• Store below 30°C, away from light and moisture

• Keep out of reach of children