Roflast Tablet 500 mcg contains Roflumilast, a selective phosphodiesterase-4 (PDE4) inhibitor used in the management of severe chronic obstructive pulmonary disease (COPD). It helps reduce inflammation in the airways and decreases the risk of exacerbations in patients with chronic bronchitis associated with COPD. This medication is not a bronchodilator but works as an anti-inflammatory agent to improve long-term respiratory health.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Roflumilast 500 mcg

Indications

Roflast Tablet is indicated for:

• Maintenance treatment of severe COPD associated with chronic bronchitis
• Reduction of COPD exacerbations in patients with a history of frequent flare-ups

It is typically used as an add-on therapy to bronchodilators.

Mechanism of Action

Roflumilast works by inhibiting the enzyme phosphodiesterase-4 (PDE4), which is involved in the breakdown of cyclic AMP (cAMP) in inflammatory cells. By increasing cAMP levels, it helps suppress the release of inflammatory mediators, leading to reduced airway inflammation and improved lung function over time.

Dosage and Administration

• The recommended dose is 500 mcg once daily or as prescribed by a physician
• Can be taken with or without food
• Swallow the tablet whole with water
• Take at the same time each day for consistent effect
• Do not use for immediate relief of acute bronchospasm

Benefits

• Reduces airway inflammation in COPD patients
• Decreases frequency of exacerbations
• Improves lung function over long-term use
• Convenient once-daily oral dosing

Possible Side Effects

Common side effects may include:

• Diarrhea
• Nausea
• Weight loss
• Headache
• Insomnia

Serious side effects may include:

• Psychiatric symptoms (anxiety, depression, mood changes)
• Severe weight loss
• Hypersensitivity reactions

Patients should seek medical attention if serious side effects occur.

Precautions and Warnings

• Not indicated for the treatment of acute bronchospasm
• Use with caution in patients with liver impairment
• Monitor weight regularly during treatment
• Caution in patients with a history of depression or suicidal thoughts
• Avoid use during pregnancy unless clearly necessary

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Roflast Tablet may interact with:

• Strong CYP450 enzyme inducers (e.g., rifampicin)
• CYP3A4 inhibitors (e.g., ketoconazole)
• Other medications affecting liver enzymes

Always inform your doctor about all medications you are taking.

Storage

• Store below 30°C in a cool, dry place
• Protect from light and moisture
• Keep out of reach of children.