Radiglip-M Tablet 50 mg + 500 mg is a combination oral antidiabetic medication containing Sitagliptin 50 mg and Metformin Hydrochloride 500 mg. It is used for the management of type 2 diabetes mellitus when blood glucose is not adequately controlled with diet, exercise, or monotherapy.

This fixed-dose combination improves glycemic control through two complementary mechanisms, targeting different aspects of glucose regulation.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Radiglip-M is indicated for:

• Treatment of type 2 diabetes mellitus

• Patients inadequately controlled with metformin alone

• Patients already taking sitagliptin and metformin separately

• Combination therapy with other antidiabetic agents when prescribed

It is not indicated for type 1 diabetes or diabetic ketoacidosis.

Mechanism of Action

Sitagliptin (DPP-4 Inhibitor)

• Inhibits the enzyme dipeptidyl peptidase-4 (DPP-4)

• Increases levels of incretin hormones (GLP-1 and GIP)

• Enhances glucose-dependent insulin secretion

• Reduces glucagon release

• Lowers postprandial and fasting blood glucose

Metformin (Biguanide)

• Decreases hepatic glucose production

• Improves insulin sensitivity

• Reduces intestinal glucose absorption

• Enhances peripheral glucose uptake

Together, these agents provide better overall glycemic control.

Dosage and Administration

• Usually taken twice daily with meals to reduce gastrointestinal side effects.

• Dosage depends on prior therapy, blood glucose levels, and renal function.

• Swallow whole with water; do not crush or chew.

Renal function should be assessed before initiation and periodically during treatment.

Benefits

• Dual mechanism for improved blood glucose control

• Low risk of hypoglycemia (when not combined with insulin or sulfonylureas)

• Weight-neutral or modest weight benefit (due to metformin)

• Convenient fixed-dose combination

• Helps control both fasting and post-meal glucose levels

Side Effects

Common side effects:

• Nausea

• Diarrhea

• Abdominal discomfort

• Headache

• Upper respiratory tract infection

Serious but rare side effects:

• Lactic acidosis (associated with metformin)

• Pancreatitis (associated with sitagliptin)

• Hypoglycemia (especially if combined with insulin or sulfonylureas)

• Allergic reactions

Seek immediate medical attention if severe abdominal pain, breathing difficulty, or unusual muscle pain occurs.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Contraindicated in severe renal impairment.

• Assess kidney function before and during treatment.

• Temporarily discontinue before iodinated contrast procedures.

• Avoid excessive alcohol intake.

• Use cautiously in patients with liver disease.

• Monitor for signs of lactic acidosis.

Contraindications

• Severe renal impairment

• Metabolic acidosis, including diabetic ketoacidosis

• Hypersensitivity to sitagliptin, metformin, or any component

Storage

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.