Primace 5 mg Tablet contains Ramipril, a well-established Angiotensin-Converting Enzyme (ACE) inhibitor used to manage high blood pressure, heart failure, and reduce cardiovascular risk. By targeting the renin-angiotensin-aldosterone system (RAAS), Ramipril relaxes blood vessels, lowers blood pressure, and decreases cardiac workload, providing both cardioprotective and renoprotective effects. It is widely prescribed for patients with hypertension, post-myocardial infarction complications, and those at risk of cardiovascular events.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Primace 5 mg Tablet is indicated for:

• Hypertension: Effective in lowering elevated blood pressure, either alone or in combination with other antihypertensive agents

• Heart failure: Improves symptoms and survival in patients with chronic heart failure

• Post-myocardial infarction: Reduces the risk of mortality and cardiovascular complications in patients recovering from heart attacks

• Cardiovascular event prevention: In high-risk patients with conditions like diabetes, coronary artery disease, or a history of stroke

• Diabetic nephropathy and chronic kidney disease: Slows progression of kidney damage in patients with proteinuric kidney disease or type 2 diabetes

Pharmacology and Mode of Action

Ramipril is a prodrug that is metabolized in the liver to ramiprilat, its active form. Ramiprilat inhibits angiotensin-converting enzyme (ACE), preventing the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This leads to:

• Vasodilation and reduced peripheral resistance

• Decreased aldosterone secretion, lowering sodium and water retention

• Reduced cardiac workload and improved tissue perfusion

The combination of blood pressure reduction and organ protection makes Ramipril particularly effective in patients with cardiovascular or renal risk factors.

Dosage and Administration

• Adults with hypertension: Typically start at 2.5–5 mg once daily, titrated according to response

• Heart failure: Initial dose 1.25–2.5 mg once daily, gradually increased as tolerated

• Post-myocardial infarction: Started under careful monitoring, usually 2.5 mg twice daily or as directed

• Elderly or renal impairment: Begin with lower doses (1.25–2.5 mg once daily) to prevent hypotension

Primace tablets should be taken orally, with or without food, preferably at the same time each day. Swallow the tablet whole with water.

Drug Interactions

• Diuretics: May enhance the hypotensive effect

• Potassium supplements or potassium-sparing diuretics: May increase the risk of hyperkalemia

• NSAIDs: Can reduce antihypertensive effect and affect kidney function

• Lithium: ACE inhibitors may elevate lithium levels, increasing risk of toxicity

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

• Hypersensitivity to Ramipril or other ACE inhibitors

• History of angioedema associated with previous ACE inhibitor therapy

• Pregnancy, especially in the second and third trimesters

• Severe renal impairment or bilateral renal artery stenosis

Side Effects

Common side effects include dizziness, headache, persistent dry cough, hypotension, and fatigue. Rare but serious effects may include angioedema, hyperkalemia, and renal dysfunction.

Precautions and Warnings

• Monitor blood pressure, renal function, and serum electrolytes regularly

• Exercise caution in elderly patients, those with impaired kidney function, or patients receiving multiple antihypertensive medications

• Discontinue immediately if signs of angioedema occur

Pregnancy and Lactation

Ramipril is contraindicated during pregnancy due to fetal toxicity. Its use in breastfeeding is not well established; alternative therapy should be considered.

Storage Conditions

Store in a cool, dry place below 30°C, protected from light and moisture. Keep out of reach of children.