Primace 1.25 mg Capsule contains Ramipril, an oral antihypertensive agent belonging to the class of ACE inhibitors (Angiotensin-Converting Enzyme inhibitors). It is widely used for the management of high blood pressure (hypertension), heart failure, and for reducing cardiovascular risk in high-risk patients. By inhibiting the angiotensin-converting enzyme, Ramipril helps relax blood vessels, lower blood pressure, and reduce the strain on the heart, improving overall cardiovascular health.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Primace 1.25 mg Capsule is indicated for:

• Hypertension: Alone or in combination with other antihypertensive agents to control high blood pressure

• Heart failure: To improve survival and reduce hospitalizations in patients with symptomatic heart failure

• Post-myocardial infarction: To reduce cardiovascular morbidity and mortality

• Prevention of cardiovascular events: In patients at high risk of myocardial infarction, stroke, or heart failure

• Diabetic nephropathy and chronic kidney disease: To slow progression of kidney damage in patients with type 2 diabetes or proteinuric renal disease

Pharmacology and Mode of Action

Ramipril is a prodrug that is converted in the liver to its active form, ramiprilat. Ramiprilat inhibits the angiotensin-converting enzyme (ACE), preventing the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This results in vasodilation, reduced blood pressure, decreased aldosterone secretion, and decreased sodium and water retention. The overall effect is reduced cardiac workload and improved organ perfusion.

Dosage and Administration

• Adults with hypertension: Initial dose is usually 2.5 mg once daily; may be titrated according to response.

• Elderly or patients with renal impairment: Lower starting dose (1.25 mg once daily) is recommended to reduce the risk of hypotension.

• Heart failure: Initial dose typically 1.25–2.5 mg once daily; gradually increased as tolerated.

• Post-myocardial infarction: Therapy is started as early as 24 hours post-event with careful monitoring of blood pressure and renal function.

Primace should be taken orally, with or without food, preferably at the same time each day. Capsules should be swallowed whole with water.

Drug Interactions

• Diuretics: Concomitant use may enhance hypotensive effects

• Potassium-sparing diuretics, potassium supplements, or salt substitutes: May increase the risk of hyperkalemia

• NSAIDs: May reduce the antihypertensive effect and increase risk of kidney dysfunction

• Lithium: ACE inhibitors may increase lithium levels and risk of toxicity

Contraindications

• Known hypersensitivity to Ramipril or other ACE inhibitors

• History of angioedema related to previous ACE inhibitor therapy

• Pregnancy (particularly in the second and third trimesters)

• Severe renal impairment or bilateral renal artery stenosis

Side Effects

Common side effects of Primace include dizziness, hypotension, headache, fatigue, cough, and gastrointestinal discomfort. Rare but serious reactions may include angioedema, hyperkalemia, and renal impairment.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Blood pressure, renal function, and electrolytes should be monitored regularly

• Use caution in patients with renal impairment, elderly patients, or those on concomitant antihypertensive therapy

• Discontinue immediately if signs of angioedema appear

Pregnancy and Lactation

Ramipril is contraindicated in pregnancy due to risk of fetal toxicity. Its safety during breastfeeding is not well established; alternative therapy should be considered.

Storage Conditions

Store capsules in a cool, dry place below 30°C, protected from light and moisture. Keep out of reach of children.