Prelizer-HTZ Tablet 5 mg + 6.25 mg is a fixed-dose combination medication containing Bisoprolol Fumarate 5 mg and Hydrochlorothiazide 6.25 mg. It is used for the management of hypertension (high blood pressure), especially in patients who require combination therapy for better blood pressure control.

This dual-action formula combines a beta-blocker with a thiazide diuretic to effectively lower blood pressure and reduce the risk of cardiovascular complications.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Prelizer-HTZ is indicated for:

• Hypertension not adequately controlled with monotherapy

• Patients requiring combination therapy to reduce cardiovascular risk

Proper blood pressure control helps prevent stroke, heart attack, heart failure, and kidney disease.

Dosage and Administration

• Typically taken once daily, preferably in the morning.

• Can be taken with or without food.

• Swallow the tablet whole with water.

• Dosage adjustments should be made according to physician guidance.

Do not discontinue abruptly, particularly due to the beta-blocker component, as sudden withdrawal may worsen heart conditions.

Mechanism of Action

Bisoprolol is a selective beta-1 adrenergic receptor blocker that:

• Slows heart rate

• Reduces cardiac output

• Lowers blood pressure

Hydrochlorothiazide is a thiazide diuretic that:

• Promotes excretion of sodium and water

• Reduces blood volume

• Contributes to lowering blood pressure

Together, they provide additive antihypertensive effects.

Benefits

• Dual mechanism for enhanced blood pressure control

• Once-daily convenient dosing

• Helps reduce risk of cardiovascular events

• Suitable for long-term hypertension management

• Lower diuretic dose may reduce electrolyte imbalance risk

Safety Information

Contraindications

• Severe bradycardia

• Cardiogenic shock

• Severe renal impairment

• Anuria

• Hypersensitivity to sulfonamides or any component

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Warnings and Precautions

• Regular monitoring of blood pressure and heart rate

• Monitor kidney function and electrolyte levels

• May mask hypoglycemia symptoms in diabetic patients

• Use cautiously in patients with gout

• Avoid abrupt discontinuation

Common Side Effects

• Dizziness

• Fatigue

• Increased urination

• Slow heart rate

• Electrolyte disturbances

Seek immediate medical attention if experiencing severe dizziness, fainting, irregular heartbeat, or signs of allergic reaction.

Storage

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.