Politrim DS Tablet 800 mg + 160 mg is a double-strength (DS) antibacterial formulation containing Sulphamethoxazole and Trimethoprim. This combination antibiotic is widely prescribed for the treatment of moderate to severe bacterial infections caused by susceptible organisms. The double-strength formulation provides a higher dose per tablet, making it suitable for adults and patients requiring stronger antibacterial therapy.

Politrim DS works through a synergistic mechanism by inhibiting two consecutive steps in the bacterial folic acid synthesis pathway. Sulphamethoxazole, a sulfonamide antibiotic, blocks the production of dihydrofolic acid, while Trimethoprim inhibits the enzyme dihydrofolate reductase, preventing the formation of tetrahydrofolic acid. Since folic acid is essential for bacterial DNA synthesis and replication, this dual inhibition effectively stops bacterial growth and leads to bacterial cell death.

Due to its broad-spectrum activity, Politrim DS is effective against a wide range of gram-positive and gram-negative bacteria.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each double-strength tablet contains:

• Sulphamethoxazole 800 mg

• Trimethoprim 160 mg

Indications

Politrim DS Tablet is indicated for the treatment of:

• Urinary tract infections (UTIs)

• Acute and chronic bronchitis

• Pneumonia caused by susceptible organisms

• Gastrointestinal infections such as bacterial diarrhea

• Skin and soft tissue infections

• Certain opportunistic infections as prescribed by a physician

Dosage and Administration

The dosage should be determined by a registered healthcare professional based on the type and severity of infection.

• Usually taken twice daily.

• Swallow the tablet whole with a full glass of water.

• May be taken with or after food to minimize gastric discomfort.

• Maintain adequate hydration during therapy.

• Complete the full prescribed course even if symptoms improve earlier.

Do not skip doses or discontinue treatment without medical advice.

Precautions and Warnings

• Use cautiously in patients with renal or hepatic impairment.

• Contraindicated in individuals with known hypersensitivity to sulfonamides or trimethoprim.

• Caution is required in elderly patients and those with folate deficiency.

• May increase sensitivity to sunlight; avoid excessive sun exposure.

• Regular blood count monitoring may be required during prolonged therapy.

Consult your doctor before using this medicine during pregnancy or breastfeeding.

Possible Side Effects

Common side effects may include:

• Nausea or vomiting

• Loss of appetite

• Skin rash

• Headache

• Mild gastrointestinal discomfort

Serious allergic reactions or severe skin reactions are rare but require immediate medical attention.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage Instructions

• Store below 30°C in a cool and dry place.

• Protect from light and moisture.

• Keep out of reach of children.

Conclusion

Politrim DS Tablet 800 mg + 160 mg (Sulphamethoxazole + Trimethoprim) is a trusted double-strength antibiotic combination for the effective treatment of moderate to severe bacterial infections. With its synergistic mechanism of action, it provides reliable antibacterial coverage when used as directed by a healthcare professional.