Patron Injection 0.25 mg/5 ml contains Palonosetron, a highly selective 5-HT3 receptor antagonist used to prevent nausea and vomiting associated with chemotherapy and surgery. Palonosetron works by blocking serotonin (5-HT3) receptors in the gastrointestinal tract and central nervous system, which play a key role in triggering the vomiting reflex.

This formulation is intended for intravenous administration, offering rapid onset and long-lasting antiemetic effects. Patron Injection is particularly useful in patients receiving moderately or highly emetogenic chemotherapy, as well as in those at risk of postoperative nausea and vomiting (PONV). It helps improve patient comfort, treatment adherence, and overall quality of life during medical procedures.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Key Benefits

• Prevents chemotherapy-induced nausea and vomiting (CINV)

• Provides protection in both acute (0–24 hours) and delayed (24–120 hours) phases of CINV

• Reduces postoperative nausea and vomiting (PONV)

• Rapid onset with intravenous administration

• Long-acting, offering extended antiemetic coverage

• Improves patient comfort and compliance during chemotherapy or surgery

Mechanism of Action

Palonosetron, the active ingredient in Patron Injection, acts as a selective 5-HT3 receptor antagonist:

1. Serotonin Receptor Blockade:

   • Chemotherapy and surgical trauma can trigger serotonin release from enterochromaffin cells in the gut.

   • Serotonin binds to 5-HT3 receptors on vagal nerve terminals, activating the vomiting center in the brain.

   • Palonosetron blocks these receptors, preventing nausea and vomiting signals.

2. Dual Peripheral and Central Action:

   • Acts on 5-HT3 receptors in both the gastrointestinal tract and central nervous system, providing comprehensive antiemetic protection.

3. Long Half-Life:

   • High receptor binding affinity and prolonged half-life allow single-dose administration to control both acute and delayed nausea effectively.

Indications

Patron Injection 0.25 mg/5 ml is indicated for:

• Prevention of chemotherapy-induced nausea and vomiting (CINV) in patients receiving moderate or highly emetogenic chemotherapy

• Prevention of postoperative nausea and vomiting (PONV) in adults undergoing surgery

• Part of multimodal antiemetic therapy to improve patient comfort and adherence to treatment

Dosage and Administration

• Adults: 0.25 mg administered intravenously as a single dose approximately 30 minutes before chemotherapy or surgical procedure.

• Pediatrics: Use only under strict medical supervision with weight-based dosing.

• Administer the injection slowly over at least 30 seconds to avoid local irritation.

• Dose adjustment is usually not required in mild to moderate hepatic or renal impairment, but consultation is recommended for severe impairment.

Precautions and Warnings

• Monitor patients with cardiac arrhythmias or prolonged QT interval.

• Use caution in pregnant and breastfeeding women; only administer if clearly necessary.

• Rare side effects include headache, constipation, fatigue, and transient liver enzyme changes.

• Avoid combination with other drugs that significantly prolong the QT interval unless monitored.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Patron Injection is generally well-tolerated. Common side effects include:

• Headache

• Constipation

• Dizziness or fatigue

Rare but serious reactions may include allergic reactions, arrhythmias, or severe hypersensitivity, requiring immediate medical attention.

Storage

Store at 2–8°C, protected from light. Do not freeze. Keep out of reach of children.

Patron Injection 0.25 mg/5 ml provides effective, long-lasting prevention of chemotherapy- and surgery-induced nausea and vomiting, ensuring patient comfort and adherence to treatment protocols.