Patron Injection 0.075 mg/1.5 ml contains Palonosetron, a selective 5-HT3 receptor antagonist used to prevent nausea and vomiting associated with chemotherapy or surgery. Palonosetron works by blocking serotonin receptors in the central nervous system and gastrointestinal tract, which are responsible for triggering the vomiting reflex.

This injection is designed for intravenous administration, ensuring rapid onset of action and high efficacy in controlling acute and delayed episodes of nausea and vomiting. Patron Injection is widely used in oncology and perioperative settings to improve patient comfort and quality of life during chemotherapy or surgical procedures.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Key Benefits

• Prevents chemotherapy-induced nausea and vomiting (CINV)

• Effective in both acute (0–24 hours) and delayed (24–120 hours) phases of CINV

• Reduces postoperative nausea and vomiting (PONV)

• Rapid onset of action with intravenous administration

• Long-acting, providing extended protection against nausea

• Safe for use in adults and pediatric patients under medical supervision

Mechanism of Action

Palonosetron, the active ingredient in Patron Injection, works as a highly selective 5-HT3 receptor antagonist:

1. Blocking Serotonin Receptors:

   • Chemotherapy and surgical procedures can trigger the release of serotonin (5-HT) from enterochromaffin cells in the gastrointestinal tract.

   • Serotonin binds to 5-HT3 receptors on vagal nerve terminals, activating the vomiting center in the brain.

   • Palonosetron blocks these receptors, preventing the transmission of signals that induce nausea and vomiting.

2. Long-Acting Effect:

   • Palonosetron has a high binding affinity and prolonged half-life, allowing a single injection to control both acute and delayed nausea.

   • Reduces the need for frequent antiemetic dosing.

3. Peripheral and Central Action:

   • Works on 5-HT3 receptors in the gut and central nervous system, providing comprehensive antiemetic protection.

Indications

Patron Injection 0.075 mg/1.5 ml is indicated for:

• Prevention of chemotherapy-induced nausea and vomiting (CINV) in patients receiving moderately or highly emetogenic chemotherapy

• Prevention of postoperative nausea and vomiting (PONV) in adults undergoing surgery

• As part of multimodal antiemetic therapy to improve patient comfort and adherence to treatment

Dosage and Administration

• Adults: 0.075 mg administered intravenously as a single dose approximately 30 minutes before the start of chemotherapy or surgery.

• Pediatrics: Dosing should be based on body weight and under strict medical supervision.

• Administer the injection slowly over 10 seconds into a vein.

• No dose adjustment is usually required in mild to moderate renal or hepatic impairment, but consult a physician for severe cases.

Precautions and Warnings

• Use with caution in patients with cardiac arrhythmias or prolonged QT interval.

• Monitor for rare side effects such as headache, constipation, or transient changes in liver enzymes.

• Pregnancy and breastfeeding women should use only if clearly needed and under medical guidance.

• Avoid combining with other drugs that significantly prolong the QT interval unless supervised.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Patron Injection is generally well-tolerated. Common side effects include:

• Headache

• Constipation

• Fatigue

• Dizziness

Rare side effects may include allergic reactions, arrhythmias, or severe hypersensitivity, requiring immediate medical attention.

Storage

Store at 2–8°C, protected from light. Do not freeze. Keep out of reach of children.

Patron Injection 0.075 mg/1.5 ml provides effective, long-lasting prevention of chemotherapy- and surgery-induced nausea and vomiting, improving patient comfort and adherence to treatment.