Ovarib Tablet 100 mg contains Olaparib, a targeted anticancer therapy classified as a poly (ADP-ribose) polymerase (PARP) inhibitor. It is primarily used in the treatment of certain cancers, including ovarian, breast, pancreatic, and prostate cancers, particularly in patients with BRCA1 or BRCA2 gene mutations.

Olaparib works by interfering with the DNA repair mechanisms in cancer cells. Cancer cells with BRCA mutations are highly dependent on PARP enzymes to repair DNA damage. By inhibiting PARP, Ovarib Tablet causes accumulation of DNA damage in these cells, leading to cell death while minimizing damage to healthy cells. This targeted mechanism allows for effective therapy with a more favorable safety profile compared to conventional chemotherapy.

Ovarib Tablet 100 mg is designed for oral administration, providing a convenient and consistent treatment option for eligible cancer patients. It is typically prescribed by oncologists as monotherapy or in combination with other therapies, depending on the type and stage of cancer.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Key Features

• Contains Olaparib 100 mg per tablet

• PARP inhibitor for targeted cancer therapy

• Effective against cancers with BRCA1/BRCA2 mutations

• Oral tablet formulation for convenient administration

• Used in ovarian, breast, pancreatic, and prostate cancers

• Supports DNA damage-induced cancer cell death while sparing healthy cells

Indications

Ovarib Tablet 100 mg is indicated for:

• Ovarian cancer: Treatment of advanced or recurrent ovarian cancer in patients with BRCA mutations

• Breast cancer: For HER2-negative, BRCA-mutated metastatic breast cancer

• Pancreatic cancer: In patients with germline BRCA-mutated metastatic pancreatic adenocarcinoma

• Prostate cancer: Treatment of metastatic castration-resistant prostate cancer with BRCA mutations

It is often prescribed after previous cancer treatments have failed or as maintenance therapy following response to platinum-based chemotherapy.

Mechanism of Action

Olaparib inhibits poly (ADP-ribose) polymerase (PARP) enzymes, which play a key role in repairing single-strand DNA breaks. In cancer cells with BRCA mutations, PARP inhibition prevents repair of DNA damage, leading to:

• Accumulation of DNA breaks

• Cancer cell apoptosis (programmed cell death)

• Reduced tumor growth and progression

This selective action makes Olaparib a precision medicine targeting cancer cells while minimizing harm to normal tissues.

Dosage and Administration

• The dosage and schedule of Ovarib Tablet 100 mg are determined by the treating oncologist based on cancer type, patient response, and tolerability

• Tablets should be swallowed whole with water, usually taken twice daily

• Can be taken with or without food

• Consistency in timing of doses is important to maintain therapeutic drug levels

Possible Side Effects

Common side effects may include:

• Nausea and vomiting

• Fatigue

• Anemia or low blood cell counts

• Loss of appetite

• Diarrhea or constipation

• Headache

Serious side effects are rare but may include bone marrow suppression, increased risk of infection, or liver dysfunction. Immediate medical attention is required if severe symptoms occur.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions

• Use under strict oncologist supervision

• Regular blood counts and liver function monitoring are recommended

• Inform the doctor of any other medications being taken to avoid drug interactions

• Not recommended during pregnancy or breastfeeding

• Patients with liver or kidney impairment require careful dose adjustment

Storage Instructions

• Store in a cool, dry place below 25°C

• Keep the tablet container tightly closed

• Protect from light and moisture

• Keep out of reach of children.