Opton 20 mg contains Esomeprazole, a proton pump inhibitor that effectively suppresses gastric acid secretion. It is widely prescribed for the treatment and long-term management of acid-related gastrointestinal disorders. By providing sustained acid control, Opton 20 mg helps relieve symptoms, promotes healing of damaged mucosa, and prevents recurrence of acid-mediated conditions.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Indications

Opton 20 mg is indicated for:

• Relief of symptoms associated with Gastroesophageal Reflux Disease (GERD), including persistent heartburn and acid regurgitation

• Treatment of erosive esophagitis

• Maintenance of healing of erosive esophagitis

• Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease when used in combination with amoxicillin and clarithromycin

• Zollinger–Ellison syndrome and other pathological hypersecretory conditions

• Duodenal and gastric ulcers caused by acid dyspepsia

• Acid-related dyspepsia

Dosage and Administration

• Healing of Erosive Esophagitis: 20–40 mg once daily for 4–8 weeks

• Maintenance of Healing: 20 mg once daily

• Symptomatic GERD: 20 mg once daily for 4 weeks; may be extended for another 4 weeks if needed

• H. pylori Eradication (Triple Therapy):

  • Esomeprazole 40 mg once daily

  • Amoxicillin 1000 mg twice daily

  • Clarithromycin 500 mg twice daily for 10 days

• Zollinger–Ellison Syndrome: 20–80 mg once daily, adjusted individually

• Acid-related Dyspepsia: 20–40 mg once daily for 2–4 weeks

• Duodenal Ulcer: 20 mg once daily for 2–4 weeks

• Gastric Ulcer: 20–40 mg once daily for 4–8 weeks

Opton 20 mg should be taken at least one hour before meals and swallowed whole. For patients with difficulty swallowing, capsule contents may be mixed with soft, cold applesauce and consumed immediately without chewing.

Mode of Action

Esomeprazole selectively inhibits the H⁺/K⁺-ATPase enzyme in gastric parietal cells, blocking the final step of acid production. As the S-isomer of omeprazole, it provides improved bioavailability and more consistent acid suppression compared to conventional proton pump inhibitors.

Drug Interactions

Esomeprazole is primarily metabolized by CYP2C19 and CYP3A4 enzymes. It may affect the absorption of drugs dependent on gastric pH, such as ketoconazole, iron salts, and digoxin. Caution is advised when used with diazepam and other CYP2C19 substrates.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

Opton 20 mg is contraindicated in patients with known hypersensitivity to esomeprazole or any component of the formulation.

Side Effects

Common side effects include:

• Headache

• Diarrhea

• Nausea

• Flatulence

• Abdominal pain

• Constipation

• Dry mouth

The type and frequency of adverse effects during long-term maintenance therapy are similar to those seen with short-term use.

Precautions and Warnings

• Symptomatic improvement does not exclude the presence of gastric malignancy

• Use with caution in patients with severe hepatic impairment

• Antacids may be used concurrently if required

Storage Conditions

Store in a dry place below 30°C. Protect from moisture and light. Keep out of reach of children.