Olmesan Plus Tablet 20 mg+12.5 mg is a fixed-dose combination of Olmesartan Medoxomil, an angiotensin II receptor blocker (ARB), and Hydrochlorothiazide, a thiazide diuretic. This combination is designed for the effective management of hypertension in patients who require more than single-drug therapy to achieve adequate blood pressure control. By acting through complementary mechanisms, Olmesan Plus helps lower blood pressure, improve cardiovascular outcomes, and reduce the risk of long-term complications.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each film-coated tablet contains:

• Olmesartan Medoxomil 20 mg

• Hydrochlorothiazide 12.5 mg

Therapeutic Class

Antihypertensive agent
Angiotensin II receptor blocker with thiazide diuretic

Mechanism of Action

Olmesartan Medoxomil is a prodrug that is converted to olmesartan after absorption. Olmesartan blocks the angiotensin II AT1 receptor, preventing vasoconstriction and aldosterone secretion, which leads to relaxation of blood vessels and reduced blood pressure. Hydrochlorothiazide acts on the distal renal tubules to increase excretion of sodium and water, reducing plasma volume and peripheral resistance. Together, these actions produce an additive blood pressure-lowering effect and enhance overall antihypertensive efficacy.

Indications

Olmesan Plus Tablet is indicated for:

• Treatment of essential hypertension

• Patients whose blood pressure is not adequately controlled with monotherapy

• Long-term blood pressure management to reduce cardiovascular risk

• Hypertensive patients at risk of heart, kidney, or stroke-related complications

It may be prescribed as initial combination therapy or as a step-up treatment based on clinical assessment.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Dosage and Administration

The usual recommended dose is one tablet once daily, taken with or without food. The tablet should be taken at the same time each day to maintain consistent blood pressure control. Dose adjustments and duration of therapy should be determined by a physician according to the patient’s response and tolerance.

Benefits and Features

• Dual-action antihypertensive therapy for enhanced blood pressure control

• Combines vasodilation and diuretic effects in a single tablet

• Reduces the risk of cardiovascular and renal complications

• Improves treatment adherence through fixed-dose combination

• Suitable for long-term hypertension management under medical supervision

Precautions and Warnings

• Not recommended during pregnancy due to potential fetal harm

• Use with caution in patients with kidney or liver impairment

• Monitor blood pressure, renal function, and electrolyte levels regularly

• Risk of dehydration or electrolyte imbalance, especially in elderly patients

• Inform the physician about all current medications before use

Possible Side Effects

Common side effects may include dizziness, headache, fatigue, increased urination, or low blood pressure. Electrolyte disturbances such as low potassium or sodium levels may occur with hydrochlorothiazide. Rarely, changes in kidney function or allergic reactions may be seen. Medical advice should be sought if side effects persist or worsen.

Storage

Store below 30°C in a cool, dry place protected from light and moisture. Keep out of reach of children.