Obecol Tablet 5 mg contains Obeticholic Acid, a farnesoid X receptor (FXR) agonist used in the management of chronic liver diseases, particularly primary biliary cholangitis (PBC). It helps improve bile flow, reduce liver inflammation, and slow disease progression. Obecol is typically used in patients who do not respond adequately to ursodeoxycholic acid or as part of combination therapy under specialist supervision.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Obeticholic Acid 5 mg

Mechanism of Action

Obeticholic Acid works by activating the farnesoid X receptor (FXR), a nuclear receptor involved in bile acid regulation. Activation of FXR reduces bile acid production in the liver and increases bile acid transport, thereby lowering toxic bile acid accumulation. This helps protect liver cells, reduce inflammation, and improve liver function over time.

Indications

Obecol Tablet 5 mg is indicated for:

• Primary biliary cholangitis (PBC)
• Chronic cholestatic liver disease (as prescribed by a specialist)
• Patients with inadequate response or intolerance to ursodeoxycholic acid

Dosage and Administration

• Should be taken strictly under the supervision of a hepatologist or physician.
• Dosage is individualized based on liver function and patient response.
• Usually taken orally with or without food.
• Do not stop or adjust the dose without medical advice.
• Regular liver function monitoring is required during treatment.

Benefits

• Helps slow progression of liver damage in PBC
• Improves bile acid metabolism and liver function
• Reduces liver inflammation and fibrosis risk
• Can be used in combination therapy for better outcomes
• Supports long-term liver health under specialist care

Side Effects

Common side effects may include:

• Itching (pruritus)
• Fatigue
• Abdominal discomfort
• Joint pain
• Rash

Serious but rare side effects:

• Worsening liver function in advanced disease
• Elevated liver enzymes
• Severe allergic reactions

Regular monitoring is essential to ensure safety.

Precautions and Warnings

• Not recommended in patients with advanced cirrhosis or liver decompensation without specialist supervision.
• Use caution in patients with severe liver impairment.
• Regular liver function tests are required during therapy.
• Dose adjustment may be necessary based on response and tolerance.
• Pregnancy and breastfeeding use should be carefully evaluated by a physician.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Obecol may interact with:

• Bile acid sequestrants (e.g., cholestyramine)
• CYP-related drugs affecting liver metabolism
• Other hepatotoxic medications

Always inform your healthcare provider about all medicines and supplements being used.

Storage

• Store below 30°C in a dry place
• Protect from moisture and direct sunlight
• Keep out of reach of children.