Nokof 375 mg Tablet is a mucolytic and expectorant medicine used in the management of a wide range of respiratory tract disorders associated with excessive, thick, or tenacious mucus production. It is formulated to improve mucus clearance from the airways, thereby easing breathing, reducing chest congestion, and relieving productive cough. Nokof 375 mg is suitable for both adult and pediatric patients when used according to medical advice and is commonly prescribed in acute as well as chronic respiratory conditions.

By modifying the composition and consistency of mucus, Nokof 375 mg supports effective expectoration and helps restore normal respiratory function. It plays an important role in conditions where abnormal mucus secretion contributes to airway obstruction and infection.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন 

Indications

Nokof 375 mg is indicated for the treatment and supportive management of:

• Acute bronchitis

• Chronic bronchitis

• Bronchial asthma

• Upper respiratory tract inflammation such as pharyngitis and laryngitis

• Bronchiectasis

• Cystic fibrosis

• Pulmonary tuberculosis

• Pneumonia with impaired mucus drainage

• Chronic sinusitis requiring mucus drainage

• Otitis media in children requiring improved middle ear drainage

Therapeutic Class

Cough Expectorants & Mucolytics

Pharmacology / Mode of Action

Nokof 375 mg works by reducing goblet cell hyperplasia, which is responsible for excessive mucus production in the respiratory tract. It exerts its mucolytic action through multiple mechanisms. The drug breaks disulphide bonds that cross-link glycoprotein molecules in thick sputum, thereby reducing mucus viscosity.

Additionally, mucus produced under the influence of Nokof 375 mg contains a higher proportion of sialomucin and a lower proportion of fucomucin, resulting in thinner, less sticky secretions. This combined effect increases sputum volume while making it easier to expel, ultimately improving mucociliary clearance and airway patency.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন 

Dosage & Administration

Nokof 375 mg should be taken with food unless otherwise directed by a physician.

• Adults:

  • Initially 2.25 g daily in divided doses

  • Maintenance dose: 1.5 g daily in divided doses as symptoms improve

• Children:

  • 2–5 years: 62.5–125 mg, four times daily

  • 6–12 years: 250 mg, three times daily

Dosage should be adjusted according to age, severity of condition, and clinical response.

Drug Interactions

No hazardous or clinically significant drug interactions have been reported with Nokof 375 mg.

Contraindications

Nokof 375 mg is contraindicated in patients with:

• Active peptic ulcer disease

• Known hypersensitivity to the drug or any of its components

Side Effects

Possible side effects may include:

• Gastrointestinal discomfort

• Nausea or diarrhea

• Gastrointestinal bleeding

• Heartburn

• Headache or dizziness

• Palpitations

• Skin rash

These effects are generally mild but require medical attention if persistent or severe.

Pregnancy & Lactation

There is no adequate information regarding the use of Nokof 375 mg during lactation. Although no teratogenic effects have been reported, the use of Nokof 375 mg is not recommended during the first trimester of pregnancy unless clearly necessary and prescribed by a physician.

Precautions & Warnings

Nokof 375 mg should be used with caution in patients with a recent history of peptic ulcer disease or recurrent gastrointestinal bleeding.

Overdose

Symptoms: Gastrointestinal disturbances
Management: Gastric lavage may be performed if necessary, followed by clinical observation.

Storage Conditions

Store in a cool and dry place, protected from light. Keep out of the reach of children.