Miraba Tablet 2.5 mg contains Mirogabalin Besylate, a novel neuropathic pain modulator designed to provide effective relief from chronic nerve pain. It is primarily indicated for patients suffering from peripheral neuropathic pain, such as that caused by diabetes or postherpetic neuralgia, offering improved quality of life by reducing pain intensity and discomfort.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Antineuropathic Agent / Calcium Channel α2δ Ligand

Indications

Miraba Tablet 2.5 mg is indicated for:

• Peripheral neuropathic pain associated with diabetic neuropathy

• Postherpetic neuralgia following shingles infection

• Chronic nerve pain where conventional analgesics are ineffective or poorly tolerated

Pharmacology

Mirogabalin Besylate is a selective ligand of the α2δ subunit of voltage-gated calcium channels in the central nervous system. By binding to this subunit, it reduces the release of excitatory neurotransmitters involved in pain signaling. This results in:

• Decreased neuronal hyperexcitability

• Reduced transmission of neuropathic pain signals

• Relief of spontaneous and stimulus-evoked pain

Miraba provides a more targeted effect with reduced central nervous system side effects compared to traditional therapies.

Dosage and Administration

• Initial dose: 2.5 mg orally, once daily

• Dose may be titrated up gradually to achieve optimal pain relief, as prescribed by a physician

• Tablets should be swallowed whole with water and can be taken with or without food

• Dose adjustments may be necessary in patients with renal impairment

• Regular monitoring of pain response and tolerability is recommended

Side Effects

Common side effects may include:

• Dizziness or drowsiness

• Headache

• Nausea

• Peripheral edema

Less common but serious side effects:

• Confusion or mood changes

• Allergic reactions (rash, itching, swelling)

• Impaired coordination or balance

Contraindications

• Known hypersensitivity to Mirogabalin or any other component of the tablet

• Severe renal impairment without dose adjustment

• Pregnancy and lactation unless clearly prescribed by a physician

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions & Warnings

• Use with caution in elderly patients or those with a history of sedation or falls

• Avoid alcohol and other CNS depressants while taking Miraba

• Not recommended for sudden-onset pain or as a primary treatment for acute pain

• Patients should be monitored for signs of central nervous system depression

Drug Interactions

• May enhance sedative effects of alcohol, benzodiazepines, or other CNS depressants

• No significant interactions with most standard medications, but dosage adjustments may be required for patients on multiple drugs

Storage

• Store in a cool, dry place below 30°C

• Keep away from direct sunlight and moisture

• Keep out of reach of children

Mode of Action

Mirogabalin Besylate selectively binds to the α2δ subunit of voltage-gated calcium channels in the CNS, inhibiting excitatory neurotransmitter release. This reduces peripheral neuropathic pain signals, providing effective pain relief for chronic nerve conditions.