Methox Tablet 2.5 mg contains Methotrexate, a potent antimetabolite and immunosuppressant widely used in the treatment of various autoimmune disorders and certain types of cancer. It works by interfering with the growth of rapidly dividing cells and modulating immune system activity, making it highly effective in controlling disease progression.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Methotrexate 2.5 mg
• Dosage Form: Oral tablet

Indications

Methox Tablet 2.5 mg is indicated for:

• Treatment of rheumatoid arthritis in patients not responding adequately to other therapies
• Management of severe psoriasis and psoriatic arthritis
• Treatment of certain malignancies such as acute lymphoblastic leukemia, lymphomas, and other cancers
• Use in selected autoimmune conditions as prescribed by a physician

Mechanism of Action

Methotrexate acts by inhibiting the enzyme dihydrofolate reductase, which is essential for DNA synthesis and cell replication. Its therapeutic effects include:

• Suppression of rapidly dividing cells (useful in cancer therapy)
• Reduction of immune system overactivity in autoimmune diseases
• Decrease in inflammation and slowing of disease progression

Dosage and Administration

• Dosage is highly individualized and must be prescribed by a physician
• For autoimmune conditions, Methotrexate is usually taken once weekly, not daily
• Tablets should be taken with or after food to reduce stomach upset
• Adequate hydration is recommended during therapy

Important: Incorrect daily use instead of weekly dosing can lead to serious toxicity.

Side Effects

Common side effects:

• Nausea, vomiting
• Loss of appetite
• Mouth ulcers
• Fatigue

Serious side effects:

• Bone marrow suppression (leading to anemia, infections)
• Liver toxicity
• Lung inflammation (pneumonitis)
• Severe skin reactions

Precautions and Warnings

• Contraindicated in pregnancy and breastfeeding due to risk of fetal harm
• Requires regular monitoring of liver function, kidney function, and blood counts
• Avoid alcohol to reduce risk of liver damage
• Use effective contraception during and after treatment
• Increased susceptibility to infections

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

• Interaction with NSAIDs, certain antibiotics, and other immunosuppressants may increase toxicity
• Folic acid supplements are often prescribed to reduce side effects
• Live vaccines should be avoided during treatment

Storage Conditions

• Store below 25°C in a dry place
• Protect from light and moisture
• Keep out of reach of children.