Megafil 20 mg is a selective phosphodiesterase type 5 (PDE5) inhibitor used for the management of erectile dysfunction (ED), benign prostatic hyperplasia (BPH), and patients experiencing both conditions simultaneously. By enhancing blood flow to the penis and relaxing smooth muscles in the prostate and bladder, Megafil 20 mg helps improve sexual performance, urinary flow, and overall quality of life for men with these conditions.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Drugs for Erectile Dysfunction

Indications

Megafil 20 mg is indicated for:

• Erectile Dysfunction (ED)

• Benign Prostatic Hyperplasia (BPH)

• Combined Erectile Dysfunction and symptoms of BPH

Pharmacology

Megafil 20 mg works by inhibiting PDE5, an enzyme that breaks down cyclic guanosine monophosphate (cGMP) in smooth muscle cells. Elevated cGMP levels lead to relaxation of smooth muscle in the corpus cavernosum, facilitating penile erection. PDE5 is also found in smooth muscles of the prostate and bladder wall; its inhibition improves urinary flow by relaxing these muscles and increasing blood circulation in the urinary tract.

Dosage and Administration

Erectile Dysfunction:

• Starting dose: 10 mg, 1 hour before sexual activity

• Dose adjustment: may increase to 20 mg or decrease to 5 mg based on efficacy and tolerability

• Maximum frequency: once daily

• Effect lasts up to 36 hours

Benign Prostatic Hyperplasia:

• Recommended dose: 5 mg once daily at the same time each day

Combined ED and BPH:

• Recommended dose: 5 mg once daily

Administration:

• Swallow the tablet whole with water

• Can be taken with or without food

Drug Interactions

Megafil 20 mg may interact with:

• Nitrates (e.g., Nitroglycerin, Isosorbide) – risk of severe hypotension

• Alpha-blockers and antihypertensives

• Alcohol

• CYP3A4 inhibitors (e.g., Ketoconazole, Ritonavir, Itraconazole)

• HIV protease inhibitors

• Grapefruit juice

• Antacids and certain anticonvulsants (e.g., Rifampin, Carbamazepine, Phenytoin, Phenobarbital)

Contraindications

• Concurrent use with nitrates

• Hypersensitivity to Megafil 20 mg or any excipients

Side Effects

Common:

• Headache

• Dyspepsia

• Back pain, myalgia

• Nasal congestion or pharyngitis

Rare but serious:

• Sudden vision or hearing loss

• Angina, myocardial infarction, stroke

• Severe hypotension or tachycardia

• Stevens-Johnson Syndrome, exfoliative dermatitis

• Changes in color vision

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions & Warnings

• Use with caution in patients with cardiovascular disease, renal or hepatic impairment

• Avoid concomitant use with alcohol or other PDE5 inhibitors

• Monitor for hypotension when used with alpha-blockers or nitrates

• Not recommended for women; pregnancy category B (use only if benefit outweighs risk)

• Nursing mothers should use caution, as data on excretion in breast milk is limited

Storage

• Store in a dry place, away from light and heat

• Keep out of reach of children

Mode of Action

Megafil 20 mg selectively inhibits PDE5, increasing cGMP levels in smooth muscles. This promotes relaxation of penile, prostatic, and bladder muscles, improving erection and urinary flow.