Lotepro G Suspension 0.5%+0.3% is a combination ophthalmic formulation containing Loteprednol Etabonate, a corticosteroid, and Gatifloxacin, a broad-spectrum fluoroquinolone antibiotic. This dual-action eye drop is specially designed for the management of inflammatory ocular conditions associated with bacterial infections or at risk of infection. By combining anti-inflammatory and antibacterial properties, Lotepro G Suspension ensures effective symptom relief while preventing or treating bacterial complications.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each ml of ophthalmic suspension contains:

• Loteprednol Etabonate 0.5%

• Gatifloxacin 0.3%

Therapeutic Class

Ophthalmic Steroid + Fluoroquinolone Antibiotic

Indications

Lotepro G Suspension is indicated for steroid-responsive inflammatory conditions of the eye where bacterial infection is present or suspected. These include:

• Post-operative ocular inflammation following eye surgery

• Inflammatory eye conditions with concurrent bacterial infection

• Prevention and treatment of post-surgical ocular infections

• Conditions affecting the palpebral and bulbar conjunctiva, cornea, and anterior segment of the eye where combined anti-inflammatory and antibacterial therapy is required

Pharmacology

Loteprednol Etabonate is a corticosteroid that reduces inflammation by inhibiting multiple inflammatory mediators. It induces phospholipase A2 inhibitory proteins, which block the release of arachidonic acid and reduce the synthesis of prostaglandins and leukotrienes. This leads to decreased redness, swelling, pain, and tissue damage associated with ocular inflammation.

Gatifloxacin is a fluoroquinolone antibiotic that works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, and repair. It is effective against a wide range of Gram-positive and Gram-negative bacteria commonly responsible for ocular infections.

The combination ensures rapid control of inflammation while simultaneously eliminating bacterial pathogens.

Dosage and Administration

The dosage of Lotepro G Suspension should be determined by a physician based on the severity of the condition.

• Typically, 1 drop is instilled into the affected eye(s) 2 to 4 times daily

• In severe cases, dosing frequency may be increased during the initial phase of treatment

• Shake the bottle well before use

• Avoid touching the dropper tip to any surface to prevent contamination

Treatment should not be discontinued prematurely, even if symptoms improve.

Benefits

• Provides combined anti-inflammatory and antibacterial action

• Reduces post-operative pain, redness, and swelling

• Helps prevent secondary bacterial infections

• Convenient combination improves patient compliance

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

Lotepro G Suspension is contraindicated in:

• Viral, fungal, or mycobacterial infections of the eye

• Patients with known hypersensitivity to loteprednol, gatifloxacin, other corticosteroids, fluoroquinolones, or any component of the formulation

Side Effects

Possible side effects include transient burning or stinging sensation, blurred vision, increased intraocular pressure, delayed wound healing, secondary infections, and, with prolonged use, risk of glaucoma or cataract formation.

Precautions and Warnings

• For ophthalmic use only

• Prolonged use of corticosteroids may increase intraocular pressure; monitoring is recommended if used for more than 10 days

• Use with caution in patients with a history of herpes simplex infection

• Contact lenses should be avoided during treatment

Pregnancy and Lactation

The safety of Lotepro G Suspension during pregnancy and lactation has not been fully established. It should be used only if the potential benefit justifies the potential risk, under medical supervision.

Storage

Store below 30°C in a cool, dry place. Protect from light. Keep out of reach of children.