Losatan HZ Tablet is a combination of Losartan Potassium and Hydrochlorothiazide used for the management of hypertension (high blood pressure). This fixed-dose combination helps lower blood pressure more effectively than either medicine alone, especially in patients who are not adequately controlled on monotherapy.

It works by relaxing blood vessels and removing excess fluid from the body, reducing the workload on the heart.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredients: Losartan Potassium + Hydrochlorothiazide
• Strength: 50 mg + 12.5 mg
• Dosage Form: Oral tablet

Mechanism of Action

This combination works through two complementary mechanisms:

Losartan Potassium:

• Blocks angiotensin II (AT1) receptors
• Relaxes blood vessels
• Reduces aldosterone secretion

Hydrochlorothiazide:

• Thiazide diuretic (water pill)
• Increases excretion of sodium and water through urine
• Reduces blood volume

Together, they provide enhanced and sustained blood pressure control.

Indications

Losatan HZ Tablet is indicated for:

• Hypertension (high blood pressure)
• Patients not adequately controlled with single-agent therapy
• Reduction of cardiovascular risk in hypertensive patients
• Management of fluid retention associated with hypertension

Dosage and Administration

• Dosage is individualized based on blood pressure response
• Commonly taken once daily with or without food
• Swallow whole with water
• Regular monitoring of blood pressure is recommended
• Dose adjustments should be done under medical supervision

Benefits

• Dual-action control of blood pressure
• More effective than single therapy in many patients
• Helps reduce risk of stroke and heart attack
• Removes excess fluid and reduces swelling
• Once-daily convenient dosing
• Suitable for long-term hypertension management

Side Effects

Common side effects may include:

• Dizziness
• Fatigue
• Increased urination
• Headache
• Low blood pressure

Less common but serious effects:

• Electrolyte imbalance (low potassium or sodium)
• Increased uric acid levels (may trigger gout)
• Kidney function changes
• Allergic reactions (rare)

Precautions and Warnings

• Use only under medical supervision
• Monitor blood pressure and electrolyte levels regularly
• Caution in patients with kidney or liver disease
• May increase sensitivity to sunlight (hydrochlorothiazide)
• Avoid potassium supplements unless prescribed
• Not recommended during pregnancy

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Use in Special Populations

• Pregnancy: Contraindicated
• Lactation: Use only if clearly needed
• Pediatrics: Not routinely recommended
• Elderly: May require dose adjustment and close monitoring

Storage

• Store below 25°C
• Protect from light and moisture
• Keep in original packaging
• Keep out of reach of children.