Lopadine Max 0.7% is a topical ophthalmic solution indicated for the treatment of ocular itching associated with allergic conjunctivitis. The active ingredient, Olopatadine Hydrochloride, is a selective histamine H1 receptor antagonist and mast cell stabilizer that provides effective relief from eye itching, redness, and irritation caused by allergies.

Lopadine Max 0.7% is formulated for once-daily use, offering convenient dosing while maintaining potent anti-allergic effects. It is suitable for adults and children and has minimal systemic absorption, reducing the risk of systemic side effects.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Ophthalmic Non-Steroidal Drugs

• Antiallergic Ophthalmic Agents

Pharmacology

Olopatadine Hydrochloride in Lopadine Max 0.7% works by:

• Inhibiting the release of histamine from mast cells

• Acting as a selective H1 receptor antagonist, blocking histamine-induced allergic responses

• Reducing ocular itching, redness, and swelling associated with type 1 hypersensitivity reactions

Olopatadine is highly selective and does not affect alpha-adrenergic, dopamine, or muscarinic receptors. Following topical ocular administration, systemic exposure is low, minimizing systemic side effects.

Indications

Lopadine Max 0.7% is indicated for:

• Ocular itching associated with allergic conjunctivitis

• Relief of redness, tearing, and irritation caused by seasonal or perennial allergies

Dosage and Administration

• 0.7% Ophthalmic Solution:

  • Adults and children: Instill one drop in each affected eye once daily

• Other concentrations:

  • 0.1%: One drop twice daily, 6–8 hours apart

  • 0.2%: One drop once daily

• Administration:

  • Shake well before use

  • Avoid touching the dropper tip to any surface to prevent contamination

  • Wait at least 10 minutes before inserting soft contact lenses

Interactions

• Concomitant use with CNS depressants may result in additive sedation effects

• Minimal systemic absorption reduces the likelihood of significant drug interactions

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

• Known hypersensitivity to Olopatadine Hydrochloride or any excipients in the formulation

Side Effects

Lopadine Max 0.7% is generally well tolerated. Reported side effects include:

• Headache: ~7% of patients

• Less than 5% incidence: asthenia, blurred vision, burning/stinging, cold syndrome, dry eye, foreign body sensation, hyperemia, hypersensitivity, keratitis, lid edema, nausea, pharyngitis, pruritus, rhinitis, sinusitis, and taste perversion

Pregnancy & Lactation

• Pregnancy: Limited data; should be used only if benefits outweigh potential risks to the fetus

• Lactation: Unknown if topical administration leads to systemic absorption sufficient to appear in breast milk; caution is advised

Precautions & Warnings

• Not intended for contact lens-related irritation

• Remove contact lenses before instillation; wait at least 10 minutes before reinsertion

• Avoid contamination of the dropper tip

• Discontinue use if severe ocular reactions occur

Overdose

• Symptoms: Drowsiness in adults; agitation followed by drowsiness in children

• Management: Supportive and symptomatic treatment

Storage Conditions

• Store in a cool, dry place below 30°C, protected from light

• Keep out of reach of children

• Do not use after 30 days of first opening

Use in Special Populations

• Geriatric: No significant differences in safety or efficacy observed compared to younger adults

• Pediatric: Safe for use in children under supervision

Mode of Action

Olopatadine in Lopadine Max 0.7% blocks histamine H1 receptors in the conjunctival tissue and prevents mast cell degranulation, providing rapid relief from ocular itching and allergic inflammation while minimizing systemic effects.