Leo Tablet 500 mg contains Levofloxacin Hemihydrate, a broad-spectrum fluoroquinolone antibiotic used to treat a wide range of bacterial infections. It is particularly effective against Gram-positive and Gram-negative bacteria, providing rapid relief from infections of the respiratory tract, urinary tract, skin and soft tissues, and gastrointestinal system. Levofloxacin is a bactericidal agent, meaning it kills bacteria by interfering with their DNA replication and repair mechanisms, ensuring effective clearance of infection.

Leo Tablet 500 mg is an oral formulation designed for once or twice-daily administration, offering convenience and high systemic absorption for optimal therapeutic effect.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each tablet contains:

• Levofloxacin Hemihydrate 500 mg

Mechanism of Action

Levofloxacin exerts its antibacterial effect by:

• Inhibiting bacterial DNA gyrase and topoisomerase IV, essential enzymes for bacterial DNA replication, transcription, and repair

• Causing DNA fragmentation and bacterial cell death

• Providing rapid bactericidal activity against a wide spectrum of pathogens, including Streptococcus pneumoniae, Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, Mycoplasma pneumoniae, and Chlamydophila pneumoniae

Its mechanism makes it effective against both common and atypical bacterial pathogens while minimizing cross-resistance with other antibiotic classes.

Indications

Leo Tablet 500 mg is indicated for the treatment of:

• Community-acquired and hospital-acquired respiratory tract infections, including pneumonia, acute bacterial sinusitis, and bronchitis exacerbations

• Complicated and uncomplicated urinary tract infections, including pyelonephritis

• Skin and soft tissue infections caused by susceptible bacteria

• Gastrointestinal infections, including infections due to Salmonella and Shigella species

• Cases where first-line antibiotics are ineffective or contraindicated

Dosage and Administration

• Adults: 500 mg orally once daily or twice daily, depending on the severity of the infection and physician’s recommendation

• Tablets should be taken with or without food, swallowed whole with a full glass of water

• Maintain adequate hydration during therapy to support kidney function

• Complete the entire prescribed course, even if symptoms improve early, to prevent recurrence and bacterial resistance

• Dose adjustments may be necessary for patients with renal impairment

Benefits

• Broad-spectrum coverage against both Gram-positive and Gram-negative bacteria

• Rapid bactericidal effect for prompt symptom relief

• Convenient oral dosing with high systemic bioavailability

• Reduces risk of infection complications and progression

• Suitable for a wide range of bacterial infections

Precautions

• Use cautiously in patients with kidney or liver impairment

• Avoid excessive sun exposure, as fluoroquinolones may cause photosensitivity

• Not recommended for children, pregnant, or breastfeeding women unless prescribed by a physician

• Inform your doctor of other medications, particularly antacids, iron, or multivitamins, which can reduce absorption

• Monitor for tendon pain or swelling, especially in elderly patients, as tendonitis or tendon rupture is a rare risk

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects may include:

• Nausea, vomiting, or diarrhea

• Headache or dizziness

• Abdominal pain

• Mild fatigue

Rare but serious side effects:

• Tendon rupture or tendonitis

• Peripheral neuropathy (tingling or numbness)

• Severe allergic reactions

• Heart rhythm disturbances (QT prolongation)

Seek immediate medical attention if severe symptoms, tendon pain, or neurological signs occur.

Storage

Store below 30°C in a cool, dry place, away from light and moisture. Keep out of reach of children.