Kilbac 500 mg contains Cefuroxime, a well-established second-generation cephalosporin antibiotic with broad-spectrum bactericidal activity. It is effective against a wide variety of Gram-positive and Gram-negative bacteria, including many β-lactamase–producing strains. Kilbac 500 mg is commonly prescribed for mild to moderately severe infections affecting the respiratory tract, skin, urinary tract, bones, and joints.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Second Generation Cephalosporins

Pharmacology

Cefuroxime exerts its antibacterial effect by inhibiting bacterial cell wall synthesis, leading to cell death. It is highly stable against bacterial β-lactamases and therefore remains effective against many organisms resistant to ampicillin and amoxicillin. This stability and broad coverage make it a reliable option for community-acquired infections.

Indications

Kilbac 500 mg is indicated for the treatment of infections caused by susceptible organisms, including:

• Pharyngitis and tonsillitis caused by Streptococcus pyogenes

• Acute bacterial otitis media caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pyogenes

• Acute bacterial maxillary sinusitis

• Lower respiratory tract infections including community-acquired pneumonia

• Acute bacterial exacerbation of chronic bronchitis and secondary bacterial infections of acute bronchitis

• Skin and skin-structure infections caused by Staphylococcus aureus and Streptococcus pyogenes

• Urinary tract infections caused by E. coli and Klebsiella pneumoniae

• Bone and joint infections caused by Staphylococcus aureus

• Gonorrhoea caused by Neisseria gonorrhoeae

• Early Lyme disease (erythema migrans) caused by Borrelia burgdorferi

• Multidrug-resistant typhoid fever, as clinically indicated

Dosage and Administration

Adults and Adolescents (13 years and older):

• Pharyngitis/Tonsillitis: 250 mg twice daily for 5–10 days

• Acute sinusitis: 250 mg twice daily for 10 days

• Chronic bronchitis exacerbation: 250–500 mg twice daily for 10 days

• Skin and skin-structure infections: 250–500 mg twice daily for 10 days

• Uncomplicated UTI: 250 mg twice daily for 7–10 days

• Community-acquired pneumonia: 250–500 mg twice daily for 5–10 days

• MDR typhoid fever: 500 mg twice daily for 10–14 days

• Early Lyme disease: 500 mg twice daily for 20 days

• Uncomplicated gonorrhoea: 1000 mg as a single dose

Paediatric Patients (3 months to 12 years):

• Pharyngitis/Tonsillitis: 20 mg/kg/day in two divided doses

• Acute otitis media and sinusitis: 30 mg/kg/day in two divided doses

• Impetigo: 30 mg/kg/day in two divided doses

Dosage should be adjusted according to severity of infection and clinical response.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

Kilbac 500 mg is contraindicated in patients with known hypersensitivity to cephalosporins.

Drug Interactions

No potentially hazardous drug interactions have been reported with cefuroxime.

Side Effects

Cefuroxime is generally well tolerated. Reported side effects are usually mild and transient and may include:

• Gastrointestinal disturbances

• Skin rashes

• Overgrowth of non-susceptible organisms such as Candida with prolonged use

Pregnancy and Lactation

Cefuroxime is classified as US FDA Pregnancy Category B. It should be used during pregnancy only when clearly needed. As cefuroxime is excreted in human milk, caution is advised when administered to breastfeeding mothers.

Precautions and Warnings

• Use with caution in patients receiving potent diuretics

• Care is advised in patients with a history of colitis

• Cephalosporins may generally be used in penicillin-allergic patients, although cross-reactivity has been reported

Storage Conditions

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.