Kilbac 250 mg is an oral antibacterial formulation containing Cefuroxime, a second-generation cephalosporin antibiotic. It is indicated for the treatment of a wide range of infections caused by susceptible Gram-positive and Gram-negative bacteria, including β-lactamase–producing strains. Kilbac 250 mg is commonly prescribed for respiratory, urinary, skin, and soft tissue infections in both adults and pediatric patients.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Second Generation Cephalosporins

Indications

Kilbac 250 mg is indicated for the treatment of infections caused by sensitive bacteria, including:

• Ear, Nose, and Throat Infections

  • Pharyngitis and tonsillitis caused by Streptococcus pyogenes

  • Acute bacterial otitis media caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis (β-lactamase producing strains), or Streptococcus pyogenes

  • Acute bacterial maxillary sinusitis caused by Streptococcus pneumoniae or Haemophilus influenzae

• Lower Respiratory Tract Infections

  • Community-acquired pneumonia

  • Acute bacterial exacerbation of chronic bronchitis

  • Secondary bacterial infections of acute bronchitis

• Skin and Skin-Structure Infections

  • Caused by Staphylococcus aureus (including β-lactamase producing strains) or Streptococcus pyogenes

• Urinary Tract Infections

  • Caused by Escherichia coli or Klebsiella pneumoniae

• Bone and Joint Infections

  • Caused by Staphylococcus aureus

• Sexually Transmitted and Other Infections

  • Gonorrhoea caused by penicillinase-producing and non-producing strains of Neisseria gonorrhoeae

  • Early Lyme disease (erythema migrans) caused by Borrelia burgdorferi

  • Multidrug-resistant typhoid fever

Pharmacology

Cefuroxime is a well-established bactericidal antibiotic that works by inhibiting bacterial cell wall synthesis. It demonstrates excellent stability against bacterial β-lactamase enzymes, allowing it to remain effective against many strains resistant to ampicillin and amoxicillin. Its broad-spectrum activity covers numerous clinically significant pathogens.

Dosage and Administration

Oral Use (Tablet or Suspension)

Adolescents and Adults (13 years and older):

• Pharyngitis/Tonsillitis: 250 mg twice daily for 5–10 days

• Acute bacterial maxillary sinusitis: 250 mg twice daily for 10 days

• Acute bacterial exacerbation of chronic bronchitis: 250–500 mg twice daily for 10 days

• Secondary bacterial infections of acute bronchitis: 250–500 mg twice daily for 5–10 days

• Uncomplicated skin and skin-structure infections: 250–500 mg twice daily for 10 days

• Uncomplicated urinary tract infections: 250 mg twice daily for 7–10 days

• Uncomplicated gonorrhoea: 1000 mg as a single dose

• Community-acquired pneumonia: 250–500 mg twice daily for 5–10 days

• MDR typhoid fever: 500 mg twice daily for 10–14 days

• Early Lyme disease: 500 mg twice daily for 20 days

Pediatric Patients (3 months to 12 years):

• Pharyngitis/Tonsillitis: 20 mg/kg/day in two divided doses for 5–10 days

• Acute otitis media: 30 mg/kg/day in two divided doses for 10 days

• Acute bacterial maxillary sinusitis: 30 mg/kg/day in two divided doses for 10 days

• Impetigo: 30 mg/kg/day in two divided doses for 10 days

Dosage should be adjusted according to the severity of infection and clinical response.

Drug Interactions

No potentially hazardous drug interactions have been reported with Cefuroxime.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

Kilbac 250 mg is contraindicated in patients with known hypersensitivity to cephalosporin antibiotics.

Side Effects

Adverse effects are generally mild and transient. Reported effects include:

• Skin rash

• Gastrointestinal disturbances such as nausea or diarrhea

Prolonged use may result in overgrowth of non-susceptible organisms, including Candida species.

Use in Pregnancy and Lactation

Cefuroxime is classified as US FDA Pregnancy Category B. It should be used during pregnancy only if clearly needed. The drug is excreted in human breast milk; therefore, caution is advised when administered to nursing mothers.

Precautions and Warnings

• Use with caution in patients receiving potent diuretics

• Caution is advised in patients with a history of colitis

• Although cross-sensitivity with penicillin may occur, cephalosporins are generally safe at recommended doses

Storage Conditions

Store in a cool, dry place below 30°C, protected from light and moisture. Keep out of the reach of children.

Mode of Action

Cefuroxime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins, leading to cell lysis and bacterial death. Its resistance to β-lactamase enzymes enhances its effectiveness against resistant bacterial strains.