Kilbac 250 mg/Vial contains Cefuroxime, a second-generation cephalosporin antibiotic with broad-spectrum bactericidal activity. It is effective against a wide range of Gram-positive and Gram-negative organisms, including many β-lactamase–producing bacteria. Kilbac is suitable for parenteral administration and is widely used in the management of mild to severe bacterial infections across multiple organ systems.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Second Generation Cephalosporin Antibiotic

Pharmacology

Cefuroxime acts by inhibiting bacterial cell wall synthesis, leading to cell lysis and death. It is stable against many bacterial β-lactamases and remains active against several ampicillin- and amoxicillin-resistant strains. Its broad antibacterial coverage makes it a reliable choice for both community-acquired and hospital-based infections.

Indications

Kilbac 250 mg/Vial is indicated for the treatment of infections caused by susceptible organisms, including:

• Upper respiratory tract infections such as pharyngitis and tonsillitis caused by Streptococcus pyogenes

• Acute otitis media caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pyogenes

• Acute bacterial maxillary sinusitis

• Lower respiratory tract infections including pneumonia

• Acute exacerbations of chronic bronchitis and secondary bacterial infections of acute bronchitis

• Skin and skin structure infections

• Urinary tract infections

• Bone and joint infections

• Gonorrhoea caused by Neisseria gonorrhoeae

• Early Lyme disease (erythema migrans) caused by Borrelia burgdorferi

• Surgical prophylaxis and serious systemic infections such as meningitis

Dosage and Administration

Dosage depends on the type and severity of infection, patient age, and clinical condition.

Adults (Parenteral):

• Standard dose: 750 mg IM or IV three times daily

• Severe infections: Up to 1.5 g IV three times daily

• Meningitis: 3 g IV three times daily

• Surgical prophylaxis: 1.5 g IV at induction of anesthesia

Children (Above 3 months):

• 30–100 mg/kg/day in divided doses

• Severe infections may require higher dosing as clinically indicated

Neonates:

• 30–100 mg/kg/day in divided doses, adjusted based on clinical response

The solution should be freshly reconstituted before use. Stability is maintained for up to 24 hours at room temperature or 48 hours under refrigeration.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

Kilbac is contraindicated in patients with known hypersensitivity to cephalosporins.

Drug Interactions

No clinically significant or hazardous drug interactions have been reported.

Side Effects

Cefuroxime is generally well tolerated. Possible adverse effects include:

• Gastrointestinal disturbances

• Skin rashes

• Overgrowth of non-susceptible organisms such as Candida with prolonged use

Use in Pregnancy and Lactation

Cefuroxime is classified as US FDA Pregnancy Category B. It should be used during pregnancy only if clearly needed. As the drug is excreted in breast milk, caution is advised when administered to nursing mothers.

Precautions and Warnings

• Use with caution in patients receiving potent diuretics

• Careful use in patients with a history of gastrointestinal disease, especially colitis

• Cross-reactivity may occur in penicillin-allergic patients, although the risk is low

Storage Conditions

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.