Janvia Tablet 100 mg contains Sitagliptin, a selective DPP-4 (Dipeptidyl Peptidase-4) inhibitor used in the management of Type 2 Diabetes Mellitus. It is designed to improve blood glucose control in adults by enhancing the body’s natural incretin hormone system. Janvia 100 mg is commonly prescribed when diet, exercise, and lifestyle modifications alone are insufficient to maintain optimal glycemic control.

Type 2 diabetes is a chronic metabolic disorder characterized by insulin resistance, reduced insulin secretion, and increased glucose production by the liver. Persistent hyperglycemia can lead to long-term complications such as cardiovascular disease, kidney damage, neuropathy, and vision problems. Janvia helps regulate blood sugar levels effectively while maintaining a low risk of hypoglycemia when used alone.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each film-coated tablet contains:

• Sitagliptin 100 mg (as Sitagliptin Phosphate)

Mechanism of Action

Sitagliptin works by inhibiting the DPP-4 enzyme, which is responsible for breaking down incretin hormones such as GLP-1 (Glucagon-Like Peptide-1) and GIP (Glucose-Dependent Insulinotropic Polypeptide). By blocking DPP-4:

• Levels of active incretin hormones increase

• Insulin secretion from pancreatic beta cells is enhanced in a glucose-dependent manner

• Glucagon secretion from alpha cells is reduced

• Hepatic glucose production decreases

This dual effect lowers both fasting and postprandial blood glucose levels. Because its action depends on elevated blood glucose, the risk of severe hypoglycemia is relatively low compared to some other antidiabetic medications.

Indications

Janvia Tablet 100 mg is indicated for:

• Management of Type 2 Diabetes Mellitus in adults

• Monotherapy when diet and exercise are inadequate

• Combination therapy with Metformin, sulfonylureas, thiazolidinediones, or insulin

• Patients requiring effective glycemic control with weight-neutral therapy

It is not indicated for Type 1 diabetes or diabetic ketoacidosis.

Dosage and Administration

The usual recommended dose is 100 mg once daily, taken with or without food. Dose adjustment is necessary in patients with moderate to severe renal impairment. The tablet should be swallowed whole with water.

Regular monitoring of blood glucose levels and HbA1c is recommended to evaluate treatment effectiveness and guide therapy adjustments.

Benefits

• Effective reduction of both fasting and post-meal blood glucose

• Once-daily convenient dosing

• Low risk of hypoglycemia when used alone

• Weight-neutral effect

• Can be safely combined with other antidiabetic agents

Precautions

• Assess renal function before starting therapy and periodically thereafter

• Use cautiously in patients with a history of pancreatitis

• Inform the physician about all current medications to avoid potential interactions

• Not recommended during pregnancy or breastfeeding unless prescribed

• Seek medical advice if severe abdominal pain or allergic reactions occur

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Janvia is generally well tolerated. Common side effects may include:

• Headache

• Nasopharyngitis

• Upper respiratory tract infection

• Mild gastrointestinal discomfort

Rare but serious side effects include pancreatitis, severe joint pain, or hypersensitivity reactions. Immediate medical attention is required if serious symptoms develop.

Storage

Store below 30°C in a cool, dry place, protected from light and moisture. Keep out of reach of children.