Intasone Injection 100 mg/2 ml contains Hydrocortisone, a synthetic corticosteroid that closely resembles the natural hormone cortisol produced by the adrenal cortex. It is used for its potent anti-inflammatory, anti-allergic, and immunosuppressive properties. Intasone Injection is primarily indicated in emergency and hospital settings where rapid corticosteroid action is required to manage acute and severe medical conditions.

Hydrocortisone helps restore adequate glucocorticoid levels in patients with adrenal insufficiency and is widely used in the treatment of inflammatory, allergic, autoimmune, and shock-related conditions.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Corticosteroids

• Glucocorticoids

Composition

Each 2 ml injection contains:

• Hydrocortisone 100 mg

Indications

Intasone Injection 100 mg/2 ml is indicated for the treatment of the following conditions:

• Acute adrenal insufficiency (Addisonian crisis)

• Severe allergic reactions, including anaphylaxis and angioedema

• Bronchial asthma and acute exacerbations of chronic obstructive pulmonary disease (COPD)

• Shock states (e.g., septic shock, traumatic shock) as adjunct therapy

• Severe inflammatory and autoimmune disorders

• Cerebral edema

• Certain hematological disorders

• Severe skin diseases and dermatoses

• Management of stress conditions where corticosteroid therapy is indicated

Pharmacology

Hydrocortisone is a glucocorticoid that exerts its effects by regulating gene expression involved in inflammatory and immune responses. It inhibits the release of inflammatory mediators such as prostaglandins and leukotrienes by suppressing phospholipase A₂ activity. This results in reduced inflammation, edema, capillary dilation, and immune cell migration.

Hydrocortisone also plays a key role in carbohydrate, protein, and fat metabolism, helps maintain blood pressure, and supports the body’s response to stress. When administered parenterally, Intasone Injection provides rapid systemic action, making it suitable for emergency use.

Dosage and Administration

Intasone Injection is intended for intravenous (IV) or intramuscular (IM) administration and should be given under medical supervision.

Adults:

• The usual dose ranges from 100 mg to 500 mg depending on the severity of the condition.

• In acute adrenal crisis, an initial dose of 100 mg IV may be followed by repeated doses or continuous infusion as directed by the physician.

Children:

• Dosage is adjusted according to body weight and clinical condition and should be determined by a healthcare professional.

Dose tapering is recommended for prolonged therapy to avoid adrenal suppression.

Contraindications

• Known hypersensitivity to hydrocortisone or any component of the formulation

• Systemic fungal infections unless appropriate antifungal therapy is provided

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

• Reduced effect with enzyme inducers such as phenytoin and rifampicin

• Increased risk of gastrointestinal bleeding with NSAIDs

• Altered blood glucose levels when used with antidiabetic agents

• Increased risk of hypokalemia with diuretics

Side Effects

Possible side effects may include:

• Fluid retention and electrolyte imbalance

• Increased blood pressure

• Hyperglycemia

• Increased susceptibility to infections

• Gastrointestinal irritation with prolonged use

Pregnancy and Lactation

Hydrocortisone should be used during pregnancy and lactation only if clearly needed and when the potential benefits outweigh the possible risks, as determined by a physician.

Storage Conditions

Store below 25°C in a cool and dry place, protected from light.
Keep out of reach of children.