Indo-A Suppository 100 mg contains Indomethacin, a potent non-steroidal anti-inflammatory drug (NSAID) designed for rectal administration. It is primarily used for the management of pain, inflammation, and fever when oral administration is not feasible, such as in patients with gastrointestinal disturbances, nausea, or difficulty swallowing. The rectal route allows for rapid absorption and effective systemic action, providing relief from acute or chronic inflammatory conditions.

Indomethacin belongs to the class of NSAIDs that inhibit cyclooxygenase (COX) enzymes, which are responsible for the synthesis of prostaglandins—chemical mediators involved in pain, inflammation, and fever. By reducing prostaglandin production, Indo-A Suppository 100 mg helps alleviate pain, reduce inflammation, and control fever efficiently.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each suppository contains:

• Indomethacin 100 mg – a non-steroidal anti-inflammatory agent

Additional excipients ensure proper consistency, stability, and rectal absorption of the medication.

Mechanism of Action

Indomethacin works through the following mechanism:

• Inhibition of cyclooxygenase (COX-1 and COX-2) enzymes: Reduces the formation of prostaglandins, which are responsible for pain, inflammation, and fever.

• Anti-inflammatory effect: Decreases swelling, redness, and tenderness in inflamed tissues.

• Analgesic effect: Relieves pain associated with musculoskeletal disorders, post-operative conditions, or acute flare-ups.

• Antipyretic effect: Lowers elevated body temperature by acting on the hypothalamic heat-regulating centers.

Rectal administration bypasses the gastrointestinal tract, reducing the risk of stomach irritation while ensuring systemic therapeutic effects.

Indications

Indo-A Suppository 100 mg is indicated for:

• Acute musculoskeletal pain, including sprains, strains, and arthritis

• Management of inflammatory conditions such as rheumatoid arthritis, osteoarthritis, or ankylosing spondylitis

• Post-operative pain and inflammation

• Fever management when oral administration is not possible

• Gout attacks or other acute inflammatory episodes

Benefits

• Rapid absorption and onset of action via rectal administration

• Effective relief of pain, inflammation, and fever

• Suitable for patients unable to take oral medications

• Provides systemic effects comparable to oral Indomethacin

• Well-suited for acute flare-ups or post-operative pain management

Dosage and Administration

• Adults: Usually 1 suppository (100 mg) rectally, 1–2 times daily, or as prescribed by a healthcare professional

• Children: Dose should be determined by a physician based on age and body weight

• Administration:

  • Wash hands thoroughly before use

  • Remove the suppository from the packaging

  • Lubricate lightly if needed and gently insert into the rectum

  • Remain lying down for a few minutes to ensure proper absorption

Do not exceed the recommended dose, and avoid prolonged continuous use without medical supervision.

Precautions

• Use cautiously in patients with gastrointestinal ulcers, bleeding disorders, or kidney/liver impairment

• Avoid use in patients with known hypersensitivity to Indomethacin or other NSAIDs

• Not recommended during the third trimester of pregnancy

• Monitor for signs of gastrointestinal bleeding, cardiovascular events, or allergic reactions

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects may include:

• Rectal irritation or discomfort

• Gastrointestinal disturbances, including nausea or mild diarrhea

• Headache or dizziness

• Rare allergic reactions or edema

Seek medical advice if severe or persistent side effects occur.

Storage

Store below 30°C in a cool, dry place, protected from moisture and light. Keep out of reach of children.

Indo-A Suppository 100 mg offers an effective and convenient alternative for managing pain, inflammation, and fever, especially in patients unable to take oral medications.