Imruza Tablet 25 mg contains Azathioprine, an immunosuppressive medication used in the management of autoimmune diseases and prevention of organ transplant rejection. It works by suppressing the immune system to reduce inflammation and prevent damage caused by abnormal immune responses. This lower-strength formulation is commonly used for dose initiation, adjustment, and maintenance therapy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each tablet contains:

• Azathioprine 25 mg

Mechanism of Action

Azathioprine is converted in the body into active metabolites that inhibit purine synthesis. This reduces the proliferation of T and B lymphocytes, which are responsible for immune responses. By suppressing these immune cells, Azathioprine helps prevent organ rejection and controls autoimmune-mediated inflammation.

Indications

Imruza Tablet 25 mg is indicated for:

• Prevention of organ transplant rejection (kidney, liver, heart)
• Rheumatoid arthritis (severe or refractory cases)
• Systemic lupus erythematosus (SLE)
• Inflammatory bowel diseases (Crohn’s disease, ulcerative colitis)
• Other autoimmune disorders as prescribed by a physician

Dosage and Administration

• To be taken orally as directed by a physician
• Dose is individualized based on body weight, condition, and response
• Often used in combination with other immunosuppressants
• Can be taken with or without food
• Regular blood monitoring is essential during therapy

Contraindications

Imruza Tablet should not be used in:

• Known hypersensitivity to Azathioprine
• Severe bone marrow suppression
• Active serious infections
• Pregnancy unless clearly prescribed by a specialist

Side Effects

Possible side effects include:

• Bone marrow suppression (low WBC, RBC, or platelets)
• Increased risk of infections
• Nausea and vomiting
• Loss of appetite
• Liver enzyme elevation
• Hair thinning

Precautions

• Regular complete blood count (CBC) and liver function tests are required
• Use cautiously in patients with liver or kidney impairment
• Avoid exposure to infections due to immunosuppression
• Use effective contraception during treatment
• Long-term use may increase risk of malignancy

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Imruza Tablet may interact with:

• Allopurinol (significantly increases toxicity risk)
• Other immunosuppressants (additive effects)
• Warfarin (may reduce effect)
• Live vaccines (should be avoided)

Storage Conditions

• Store below 30°C in a dry place
• Protect from light and moisture
• Keep out of reach of children.