I-Penam 500 mg/Vial contains Meropenem, a broad-spectrum carbapenem antibiotic for parenteral use. It is designed for the treatment of severe and complicated infections caused by susceptible single or multiple bacterial pathogens. Due to its strong bactericidal activity and high stability against beta-lactamases, I-Penam is widely used in hospital settings, including intensive care units, for life-threatening infections in both adults and children.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Other Beta-lactam Antibiotics

Indications

I-Penam 500 mg/Vial is indicated for the treatment of the following infections caused by organisms sensitive to meropenem:

• Pneumonia and nosocomial pneumonia

• Urinary tract infections

• Intra-abdominal infections

• Gynaecological infections, including endometritis and pelvic inflammatory disease

• Skin and skin structure infections

• Meningitis

• Septicaemia

• Pulmonary infections in cystic fibrosis

• Empiric treatment of presumed infections in patients with febrile neutropenia

Pharmacology

Meropenem is a carbapenem antibiotic that exerts its bactericidal action by inhibiting bacterial cell wall synthesis. It penetrates bacterial cell walls efficiently and binds with high affinity to penicillin-binding proteins (PBPs), leading to rapid bacterial cell death. Meropenem is highly stable against most serine beta-lactamases and demonstrates potent activity against a wide range of Gram-positive, Gram-negative, aerobic, and anaerobic bacteria.

Dosage

Dosage and duration depend on the type, severity of infection, and patient condition.

Adults:

• Usual dose: 500 mg to 1 g IV every 8 hours

• Pneumonia, UTI, gynaecological, skin infections: 500 mg IV every 8 hours

• Nosocomial pneumonia, septicaemia, neutropenic infections: 1 g IV every 8 hours

• Intra-abdominal infections: 500 mg to 1 g IV every 8 hours

• Cystic fibrosis: Up to 2 g IV every 8 hours

• Meningitis: 2 g IV every 8 hours

Children:

• 3 months to 12 years: 10–40 mg/kg IV every 8 hours

• Intra-abdominal infections: 20 mg/kg every 8 hours

• Cystic fibrosis (4–18 years): 25–40 mg/kg every 8 hours

• Meningitis: 40 mg/kg every 8 hours

• Febrile neutropenia: 20 mg/kg every 8 hours

• Children over 50 kg: Adult dosage

Administration

I-Penam should be administered intravenously as:

• Infusion over 15–30 minutes, or

• IV bolus injection over 3–5 minutes

Drug Interactions

• Probenecid increases plasma concentration by reducing renal excretion

• May reduce serum levels of valproic acid, increasing seizure risk

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

• Hypersensitivity to meropenem or other beta-lactam antibiotics

Side Effects

• Injection site reactions including pain and thrombophlebitis

• Skin rash, pruritus, urticaria

• Gastrointestinal disturbances such as nausea, vomiting, diarrhea

• Headache

Pregnancy & Lactation

Pregnancy Category B. Use during pregnancy only if clearly needed. Caution is advised during breastfeeding as meropenem may be excreted in human milk.

Precautions & Warnings

• Discontinue immediately if allergic reactions occur

• Monitor liver function in patients with hepatic disease

• Dosage adjustment required in renal impairment

Storage Conditions

Store vials below 30°C in a cool, dry place, protected from light and moisture. Keep out of reach of children.