Hemadus Tablet 50 mg contains roxadustat, an oral anti-anemia medication used for the treatment of anemia associated with chronic kidney disease (CKD). It works by stimulating the body’s natural production of red blood cells, helping improve hemoglobin levels and reducing fatigue, weakness, and other symptoms of anemia. This lower-strength formulation is often used for dose titration and individualized therapy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Roxadustat 50 mg
• Dosage Form: Oral tablet

Mechanism of Action

Roxadustat is a hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor. It stabilizes hypoxia-inducible factor (HIF), which increases endogenous erythropoietin production from the kidneys and liver. It also improves iron metabolism by reducing hepcidin levels, enhancing iron absorption and utilization, thereby supporting effective red blood cell formation.

Indications

Hemadus Tablet 50 mg is indicated for:

• Anemia associated with chronic kidney disease (CKD) in non-dialysis patients
• Anemia in dialysis-dependent CKD patients
• Low hemoglobin levels due to impaired kidney function
• Patients requiring dose adjustment during roxadustat therapy

Dosage and Administration

• Dosage is individualized based on hemoglobin levels and physician guidance
• Commonly taken 3 times per week
• Can be taken with or without food
• Regular monitoring of hemoglobin, iron status, and blood pressure is required
• Dose adjustments should only be made under medical supervision

Benefits

• Helps increase hemoglobin levels naturally
• Reduces symptoms of anemia such as fatigue and weakness
• Improves iron utilization in the body
• Oral administration offers convenience over injectable therapies
• Supports long-term management of CKD-related anemia

Possible Side Effects

Common side effects may include:

• Nausea
• Headache
• Dizziness
• Swelling (edema)
• Increased blood pressure

Serious side effects may include:

• Risk of blood clots (thromboembolic events)
• Cardiovascular complications
• Severe hypertension
• Abnormal liver function tests

Precautions and Warnings

• Regular monitoring of hemoglobin and blood pressure is essential
• Use cautiously in patients with cardiovascular disease
• Not recommended during pregnancy or breastfeeding unless advised by a physician
• Iron deficiency should be corrected before and during therapy
• Must be used only under strict medical supervision

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage

• Store below 30°C in a cool, dry place
• Protect from light and moisture
• Keep out of reach of children

Conclusion

Hemadus Tablet 50 mg (Roxadustat) is an effective oral therapy for managing anemia in chronic kidney disease. By stimulating natural erythropoietin production and improving iron metabolism, it helps restore hemoglobin levels and improve patient quality of life when used under proper medical supervision.