Glyxam Tablet 25 mg + 5 mg is a combination of Empagliflozin and Linagliptin used for the management of type 2 diabetes mellitus. This dual-action therapy helps improve glycemic control through complementary mechanisms—Empagliflozin increases urinary glucose excretion, while Linagliptin enhances incretin hormone activity to regulate insulin and glucagon balance. It is used when single-agent therapy is insufficient to control blood glucose levels.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each tablet contains:

• Empagliflozin 25 mg
• Linagliptin 5 mg

This higher-strength combination provides enhanced glycemic control in appropriate patients under medical supervision.

Indications

Glyxam Tablet is indicated for:

• Type 2 diabetes mellitus
• Patients inadequately controlled with monotherapy or other combinations
• Adjunct to diet and exercise for better glycemic control
• Adult diabetic patients requiring dual-mechanism therapy

Pharmacological Action

This combination works through two complementary pathways:

• Empagliflozin: Inhibits SGLT2 in the kidneys, reducing glucose reabsorption and increasing urinary glucose excretion independent of insulin
• Linagliptin: Inhibits DPP-4 enzyme, increasing incretin hormones (GLP-1 and GIP), which enhance insulin secretion and suppress glucagon release

Together, they provide effective control of fasting and postprandial blood glucose levels.

Dosage & Administration

• Usual dose: 1 tablet once daily or as directed by physician
• Can be taken with or without food
• Swallow tablet whole with water
• Maintain adequate hydration during therapy
• Dosage should be individualized based on patient response

Side Effects

Possible side effects include:

• Urinary tract infections
• Genital fungal infections
• Increased urination
• Headache
• Nasopharyngitis
• Hypoglycemia (when combined with insulin or sulfonylureas)
• Mild gastrointestinal discomfort

Contraindications

• Type 1 diabetes mellitus
• Diabetic ketoacidosis
• Hypersensitivity to Empagliflozin or Linagliptin

Precautions & Warnings

• Monitor kidney function regularly during therapy
• Maintain adequate hydration
• Increased risk of urinary and genital infections
• Use cautiously in elderly patients or those on diuretics
• Temporary discontinuation may be required during surgery or acute illness

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Use in Pregnancy & Lactation

This combination is not recommended during pregnancy or breastfeeding. Insulin is preferred for diabetes management in such cases.

Storage

• Store below 30°C
• Protect from moisture and heat
• Keep in original packaging
• Keep out of reach of children.