Glipita Tablet 100 mg contains Sitagliptin, an oral antidiabetic medication belonging to the dipeptidyl peptidase-4 (DPP-4) inhibitor class. It is used for the management of type 2 diabetes mellitus to help improve glycemic control. Glipita Tablet is commonly prescribed as part of a comprehensive diabetes treatment plan that includes diet, exercise, and other antidiabetic medicines when required.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Sitagliptin 100 mg

• Dosage Form: Oral tablet

Therapeutic Class

• Antidiabetic agent

• DPP-4 inhibitor

Indications

Glipita Tablet is indicated for:

• Type 2 diabetes mellitus in adults

• Use as monotherapy when diet and exercise alone do not provide adequate glycemic control

• Use in combination with other antidiabetic agents such as metformin, sulfonylureas, insulin, or thiazolidinediones

It is not indicated for the treatment of type 1 diabetes mellitus or diabetic ketoacidosis.

Mechanism of Action

Sitagliptin works by selectively inhibiting the DPP-4 enzyme, which is responsible for the breakdown of incretin hormones such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). By increasing incretin levels, Glipita enhances glucose-dependent insulin secretion from pancreatic beta cells and reduces glucagon release from alpha cells. This dual action leads to better blood glucose control, particularly after meals, without causing significant hypoglycemia when used alone.

Dosage and Administration

• The usual recommended dose is 100 mg once daily, taken orally with or without food.

• Dosage adjustments may be required in patients with renal impairment.

• Tablets should be swallowed whole with water.

Treatment should be continued as prescribed by a healthcare professional, along with appropriate lifestyle modifications.

Use in Special Populations

• Elderly Patients: Generally well tolerated; renal function should be monitored.

• Renal Impairment: Dose reduction is necessary depending on the severity of kidney dysfunction.

• Hepatic Impairment: Use with caution in severe hepatic disease.

• Pregnancy and Lactation: Use only if clearly needed and prescribed by a physician.

Side Effects

Glipita Tablet is usually well tolerated. Possible side effects include:

• Headache

• Nasopharyngitis

• Upper respiratory tract infection

• Gastrointestinal discomfort

• Rarely, pancreatitis or hypersensitivity reactions

Patients should seek medical attention if severe abdominal pain or allergic symptoms occur.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Sitagliptin has a low potential for drug interactions. However, caution is advised when used with:

• Insulin or sulfonylureas, due to increased risk of hypoglycemia

• Strong CYP3A4 or P-glycoprotein inhibitors in patients with renal impairment

Regular monitoring of blood glucose is recommended during combination therapy.

Storage

• Store below 30°C

• Protect from moisture and direct sunlight

• Keep out of reach of children

Advantages of Glipita Tablet

• Once-daily convenient dosing

• Effective postprandial glucose control

• Low risk of hypoglycemia when used alone

• Weight-neutral antidiabetic therapy

• Suitable for combination treatment regimens.