Gefinix Tablet 250 mg contains Gefitinib, a targeted anticancer medicine belonging to the class of tyrosine kinase inhibitors (TKIs). It is primarily used in the treatment of non-small cell lung cancer (NSCLC) that expresses specific mutations in the epidermal growth factor receptor (EGFR). By targeting abnormal cancer cell signaling pathways, Gefitinib helps slow tumor growth and improve disease control in eligible patients.

This medicine is used only under the supervision of an experienced oncologist and is an important option in personalized cancer therapy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each film-coated tablet contains:

• Gefitinib 250 mg

Mechanism of Action

Gefitinib works by selectively inhibiting the epidermal growth factor receptor (EGFR) tyrosine kinase enzyme. EGFR is responsible for activating signaling pathways that promote cell growth, division, and survival. In certain cancers, EGFR becomes overactive or mutated, leading to uncontrolled tumor growth.

By blocking EGFR activity, Gefitinib interrupts these signals, leading to reduced cancer cell proliferation, induction of cancer cell death (apoptosis), and slowing of tumor progression.

Indications

Gefinix Tablet 250 mg is indicated for:

• First-line treatment of EGFR mutation-positive non-small cell lung cancer (NSCLC)
• Locally advanced or metastatic NSCLC
• Patients with confirmed EGFR activating mutations
• Cases where chemotherapy is not suitable or as per oncologist recommendation

Dosage and Administration

• Recommended dose is usually once daily or as prescribed by the physician
• Should be taken orally with or without food
• Tablet should be swallowed whole with water
• Treatment should continue as long as clinical benefit is observed
• Regular monitoring through imaging and clinical evaluation is essential

Dose adjustments may be required based on liver function and patient tolerance.

Contraindications

Gefinix Tablet should not be used in:

• Known hypersensitivity to Gefitinib or any tablet components
• Severe liver impairment without medical supervision
• Pregnancy and breastfeeding unless clearly advised by a specialist

Side Effects

Common side effects include:

• Skin rash and acne-like eruptions
• Diarrhea
• Nausea and vomiting
• Loss of appetite
• Fatigue
• Dry skin

Serious but less common effects may include:

• Interstitial lung disease (rare but serious)
• Liver function abnormalities
• Severe diarrhea leading to dehydration

Precautions

• EGFR mutation testing should be confirmed before starting therapy
• Liver function tests should be monitored regularly
• Patients should be observed for respiratory symptoms such as cough or breathing difficulty
• Use cautiously in patients with pre-existing lung disease
• Adequate hydration and skin care are recommended during treatment

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Gefinix Tablet may interact with:

• CYP3A4 inducers or inhibitors (may affect drug levels)
• Acid-reducing agents (may reduce absorption)
• Warfarin (monitoring of INR may be required)
• Herbal supplements such as St. John’s Wort (may reduce effectiveness)

Storage Conditions

• Store below 30°C in a dry place
• Protect from light and moisture
• Keep out of reach of children.