Fluconal Tablet 150 mg contains Fluconazole, a highly effective triazole antifungal agent used for the treatment of various fungal infections in adults and children. Fluconazole works by inhibiting the fungal cytochrome P450 enzyme 14α-demethylase, which is crucial for the synthesis of ergosterol, a key component of the fungal cell membrane. Disruption of ergosterol production weakens the fungal cell membrane, leading to cell death or inhibition of growth, depending on the severity of infection.

Fluconal Tablet 150 mg is particularly used for the treatment of vaginal candidiasis, systemic fungal infections, oropharyngeal and esophageal candidiasis, and cryptococcal meningitis. The oral tablet form ensures convenient administration, excellent absorption, and consistent systemic bioavailability, making it suitable for both acute and chronic fungal infections.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Fluconal Tablet 150 mg is indicated for:

• Vaginal candidiasis (yeast infections)

• Oropharyngeal and esophageal candidiasis

• Systemic fungal infections caused by susceptible fungi

• Cryptococcal meningitis

• Prophylaxis in immunocompromised patients to prevent fungal infections

This medication should be prescribed only when a fungal infection is confirmed or strongly suspected, to prevent unnecessary use and resistance.

Mechanism of Action

• Inhibition of ergosterol synthesis: Fluconazole selectively inhibits 14α-demethylase, an enzyme required for ergosterol production in fungal cell membranes.

• Fungistatic or fungicidal effect: Inhibition of ergosterol leads to weakened cell membranes, preventing fungal growth or causing fungal death.

• Broad-spectrum activity: Effective against Candida albicans, Candida glabrata, Candida tropicalis, Cryptococcus neoformans, and other susceptible fungi.

Dosage and Administration

Dosage varies depending on the type and severity of the fungal infection:

• Vaginal candidiasis (adults): 150 mg orally as a single dose

• Oropharyngeal and esophageal candidiasis: 100–200 mg daily, depending on severity, for 1–2 weeks or as prescribed

• Systemic infections and cryptococcal meningitis: Dose may range from 200–400 mg daily, adjusted by a healthcare professional

• Children: Dose is calculated based on body weight (typically 3–6 mg/kg/day)

• Tablets can be taken with or without food

• Complete the prescribed course to prevent recurrence and resistance

Benefits and Features

• Effective against a wide range of superficial and systemic fungal infections

• Convenient single-dose or short-course therapy for vaginal yeast infections

• Excellent oral bioavailability and rapid systemic absorption

• Well-tolerated with minimal systemic side effects

• Supports prophylaxis in immunocompromised individuals

Side Effects

Fluconal Tablet 150 mg is generally well tolerated. Potential side effects may include:

• Gastrointestinal disturbances: nausea, vomiting, abdominal pain, diarrhea

• Headache or dizziness

• Mild skin rash or itching

• Rarely, hepatotoxicity or elevated liver enzymes

• Serious reactions such as severe allergic reactions or arrhythmias are uncommon but require immediate medical attention

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Use with caution in patients with hepatic or renal impairment

• Monitor liver function during prolonged therapy

• Avoid use in patients with known hypersensitivity to fluconazole or other azoles

• May interact with medications metabolized by CYP450 enzymes, including anticoagulants, anti-arrhythmics, and certain statins

• Not recommended during pregnancy unless prescribed by a healthcare professional

• Keep out of reach of children

Storage Conditions

Store Fluconal Tablet 150 mg in a cool, dry place below 30°C, protected from light and moisture. Keep tablets in their original packaging until use.

Fluconal Tablet 150 mg is an effective, safe, and convenient antifungal therapy for the treatment and prevention of various fungal infections, providing rapid relief and proven clinical efficacy.