Ferintus 100 mg Injection is a parenteral iron preparation containing Ferric Carboxymaltose, designed for the effective treatment of iron deficiency anemia in adult patients. It is especially indicated for individuals who are unable to tolerate oral iron therapy, have shown an inadequate response to oral iron supplements, or suffer from non-dialysis dependent chronic kidney disease. Ferintus provides a reliable and rapid method of replenishing iron stores when oral administration is ineffective or impractical.

Iron deficiency anemia is a common clinical condition that can significantly impact quality of life, leading to symptoms such as fatigue, weakness, shortness of breath, and reduced physical performance. Ferintus 100 mg offers a controlled and efficient intravenous option to restore iron levels and support normal hemoglobin synthesis.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Parenteral Iron Preparations

Indications

Ferintus 100 mg is indicated for the treatment of iron deficiency anemia in adult patients:

• With intolerance to oral iron therapy

• With unsatisfactory response to oral iron supplements

• With non-dialysis dependent chronic kidney disease

Pharmacology

Ferintus 100 mg is a non-dextran intravenous formulation of iron, consisting of a colloidal iron hydroxide complexed with carboxymaltose, a carbohydrate polymer. This structure allows controlled release of iron into the bloodstream. After intravenous administration, the complex is taken up by macrophages of the reticuloendothelial system, where iron is gradually released and binds to transferrin.

The transported iron is then delivered to target tissues such as the liver, spleen, and bone marrow, where it is incorporated into hemoglobin, myoglobin, and iron-dependent enzymes. Through this mechanism, Ferintus effectively restores depleted iron stores and improves oxygen transport capacity via hemoglobin.

Dosage and Administration

The dosage of Ferintus 100 mg is expressed in terms of elemental iron. Each mL contains 50 mg of elemental iron.

• Patients ≥ 50 kg:
  Two doses of 750 mg each, administered at least 7 days apart
  Maximum cumulative dose: 1500 mg per treatment course

• Patients < 50 kg:
  Two doses of 15 mg/kg body weight, administered at least 7 days apart
  Maximum cumulative dose: 1500 mg per treatment course

Ferintus may be administered intravenously as:

• A slow IV push at approximately 100 mg (2 mL) per minute, or

• An IV infusion diluted in up to 250 mL of 0.9% sodium chloride solution and administered over at least 15 minutes

Treatment may be repeated if iron deficiency anemia recurs.

Side Effects

Commonly reported adverse effects include:

• Nausea and vomiting

• Headache and dizziness

• Flushing

• Hypertension or hypotension

• Decreased blood phosphorus

• Injection site discoloration

Serious but rare reactions include hypersensitivity and anaphylactic or anaphylactoid reactions.

Contraindications

Ferintus 100 mg is contraindicated in patients with known hypersensitivity to ferric carboxymaltose or any of its components.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

Serious hypersensitivity reactions, including life-threatening anaphylaxis, have been reported. Patients should be closely monitored during and for at least 30 minutes after administration. Transient increases in blood pressure may occur and typically resolve within a short time. Administration should only be performed in settings equipped for emergency management.

Pregnancy and Lactation

Pregnancy Category C. Ferintus should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution is advised when administered to breastfeeding women.

Storage Conditions

Store below 30°C. Do not freeze. Protect from light.