Exium Injection 40 mg/vial contains Esomeprazole, a proton pump inhibitor (PPI) used for the short-term treatment of acid-related gastrointestinal disorders when oral administration is not possible or appropriate. It works by significantly reducing the amount of acid produced in the stomach, helping to relieve symptoms and promote healing of acid-related damage in the digestive tract.

Esomeprazole is the S-isomer of omeprazole and is known for its strong and long-lasting acid suppression. Exium Injection is typically administered in a hospital or clinical setting by healthcare professionals. It is commonly used in patients who cannot take oral medications due to severe illness, surgery, or difficulty swallowing.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

This medication is widely used in the treatment of gastroesophageal reflux disease (GERD), erosive esophagitis, and peptic ulcer disease. It is also used to reduce the risk of rebleeding in patients with bleeding gastric or duodenal ulcers after endoscopic treatment. By suppressing gastric acid secretion, the injection helps stabilize blood clots and supports ulcer healing.

Exium Injection is also prescribed to prevent stress-related gastric ulcers in critically ill patients and to manage conditions associated with excessive acid secretion such as Zollinger–Ellison syndrome. The drug acts directly on the acid-producing cells of the stomach to inhibit the final step in acid formation, providing rapid and effective control of gastric acidity.

Because it is given intravenously, Exium Injection provides quick therapeutic effects and ensures accurate dosing in patients who require immediate acid suppression. Once the patient’s condition improves, treatment is often switched to oral esomeprazole for continued management.

Composition

• Esomeprazole 40 mg per vial

Indications

Exium Injection 40 mg/vial is indicated for:

• Gastroesophageal reflux disease (GERD)

• Erosive esophagitis

• Gastric and duodenal ulcers

• Prevention of rebleeding after endoscopic treatment of bleeding ulcers

• Stress ulcer prophylaxis in critically ill patients

• Zollinger–Ellison syndrome and other hypersecretory conditions

• Short-term treatment when oral therapy is not feasible

Mechanism of Action

Esomeprazole works by inhibiting the proton pump (H+/K+ ATPase enzyme) located in the gastric parietal cells of the stomach. This enzyme is responsible for the final step in the production of stomach acid. By blocking this process, esomeprazole significantly reduces gastric acid secretion, allowing ulcers and inflamed tissues to heal and relieving symptoms associated with acid reflux.

Dosage and Administration

• Exium Injection is administered intravenously by a healthcare professional.

• The usual recommended dose is 40 mg once daily, depending on the patient’s condition.

• It may be given as a slow intravenous injection or infusion.

• The duration of treatment depends on the medical condition and response to therapy.

• Patients are usually switched to oral esomeprazole as soon as possible.

Possible Side Effects

Some patients may experience mild to moderate side effects, including:

• Headache

• Nausea or vomiting

• Abdominal pain

• Diarrhea or constipation

• Injection site reactions

• Dizziness

Rare but serious side effects may include severe allergic reactions, kidney problems, or electrolyte imbalances with prolonged use.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Use cautiously in patients with severe liver impairment.

• Long-term use of proton pump inhibitors may increase the risk of vitamin B12 deficiency, magnesium deficiency, or bone fractures.

• Patients should inform their doctor about all medications they are taking to avoid potential drug interactions.

• The injection should only be administered under medical supervision.

Storage

• Store below 30°C in a cool and dry place.

• Protect from light and moisture.

• Keep out of reach of children.