Eval CR Tablet 300 mg is a controlled-release formulation containing Sodium Valproate, a widely used anticonvulsant and mood-stabilizing agent. It is primarily prescribed for the management of epilepsy, including generalized tonic-clonic, absence, and complex partial seizures. Additionally, it is indicated for bipolar disorder to control manic episodes and stabilize mood, as well as for the prevention of migraine headaches.

The controlled-release (CR) technology in Eval CR Tablet 300 mg allows gradual and sustained absorption of Sodium Valproate, maintaining stable plasma concentrations over time. This reduces fluctuations that can lead to side effects, supports once- or twice-daily dosing, and improves adherence in patients requiring long-term therapy.

Epilepsy is caused by abnormal electrical activity in the brain, resulting in recurrent seizures that can disrupt daily life, cognitive function, and safety. Eval CR Tablet 300 mg helps stabilize neuronal activity, reduce seizure frequency, and improve overall quality of life. The CR formulation is also suitable for patients who require higher doses while minimizing peak-related side effects.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Key Features and Benefits

Active Ingredient:

• Sodium Valproate 300 mg per controlled-release tablet

Effective Seizure Control:

• Reduces frequency and severity of generalized tonic-clonic, absence, and partial seizures

• Suitable for monotherapy or adjunct therapy

• Helps prevent recurrence of seizures with long-term use

Mood Stabilization:

• Manages manic and mixed episodes in bipolar disorder

• Reduces emotional instability and mood swings

• Supports improved mental health and daily functioning

Migraine Prophylaxis:

• Reduces frequency, intensity, and duration of migraine attacks

• Supports better quality of life and daily productivity

Controlled-Release Technology:

• Provides steady drug release over time for consistent therapeutic effect

• Minimizes peak-related side effects such as dizziness, drowsiness, and gastrointestinal discomfort

• Supports convenient once- or twice-daily dosing

How It Works

Sodium Valproate acts through multiple mechanisms to regulate brain activity:

1. Enhancement of GABA activity: Increases gamma-aminobutyric acid (GABA) levels, the brain’s inhibitory neurotransmitter, reducing excessive neuronal firing.

2. Modulation of ion channels: Blocks voltage-gated sodium and calcium channels, preventing abnormal electrical discharges in the brain.

3. Neuroprotective effects: Protects neurons from damage caused by repeated seizure activity.

The controlled-release formulation ensures steady plasma levels, optimizing seizure control and mood stabilization while reducing the risk of side effects associated with peak concentrations.

Indications

Eval CR Tablet 300 mg is indicated for:

• Generalized tonic-clonic seizures

• Absence seizures

• Complex partial seizures

• Bipolar disorder (manic and mixed episodes)

• Migraine prophylaxis

Dosage and Administration

• Take orally as directed by a healthcare professional, preferably with food to reduce gastrointestinal irritation.

• Swallow the tablet whole; do not crush, chew, or break it, as this will compromise the controlled-release mechanism.

• Dosage is individualized based on clinical response, age, weight, and coexisting conditions.

• Regular monitoring of liver function, blood counts, and plasma levels is recommended for long-term therapy.

• Do not stop therapy abruptly to prevent seizure recurrence or mood destabilization.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Safety Information

• Inform your doctor if you have liver disease, kidney impairment, pancreatitis, or blood disorders.

• Common side effects include nausea, vomiting, dizziness, drowsiness, tremor, and weight gain.

• Rare but serious side effects include hepatotoxicity, pancreatitis, thrombocytopenia, and severe allergic reactions. Seek immediate medical attention if these occur.

• Avoid alcohol, as it may enhance drowsiness and impair seizure control.

• Use caution while driving or operating machinery until you understand the medication’s effect on alertness.

Storage Instructions

• Store below 30°C in a cool, dry place.

• Keep the container tightly closed and protected from light and moisture.

• Keep out of reach of children.

Eval CR Tablet 300 mg provides effective seizure management, mood stabilization, and migraine prevention through its controlled-release mechanism. Its steady plasma levels, convenient dosing, and reliable therapeutic action make it suitable for long-term management of epilepsy, bipolar disorder, and migraine prophylaxis under medical supervision.