Esona Tablet 375 mg + 20 mg is a combination of Naproxen Sodium and Esomeprazole Magnesium. It is designed to provide effective relief from pain and inflammation while reducing the risk of gastric irritation caused by NSAID therapy. Naproxen acts as a potent anti-inflammatory and analgesic agent, while Esomeprazole protects the stomach by decreasing acid secretion.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Esona Tablet is indicated for:

• Osteoarthritis
• Rheumatoid arthritis
• Ankylosing spondylitis
• Acute musculoskeletal pain
• Inflammatory conditions associated with pain and swelling
• Patients at risk of NSAID-induced gastric ulcers

Mechanism of Action

This combination works through two complementary mechanisms:

Naproxen Sodium:

• A non-steroidal anti-inflammatory drug (NSAID)
• Inhibits cyclooxygenase (COX-1 and COX-2) enzymes
• Reduces prostaglandin production
• Provides pain relief, anti-inflammatory, and antipyretic effects

Esomeprazole Magnesium:

• Proton pump inhibitor (PPI)
• Suppresses gastric acid secretion
• Protects gastric mucosa from NSAID-induced damage

Together, they ensure effective pain control with improved gastrointestinal safety.

Dosage and Administration

• Dosage should be determined by a physician based on condition severity
• Commonly taken once or twice daily
• Take with water, preferably before meals
• Swallow tablet whole; do not crush or chew
• Use the lowest effective dose for the shortest duration necessary

Benefits

• Effective relief from pain and inflammation
• Reduces risk of NSAID-associated gastric ulcers
• Suitable for long-term management of chronic inflammatory conditions
• Convenient fixed-dose combination
• Improves patient compliance and treatment safety

Possible Side Effects

Common side effects may include:

• Nausea
• Abdominal discomfort
• Headache
• Dizziness
• Constipation or diarrhea

Less common but serious side effects:

• Gastrointestinal bleeding or ulceration
• Kidney or liver dysfunction
• Increased risk of cardiovascular events with long-term NSAID use
• Severe allergic reactions

Seek immediate medical attention if serious symptoms occur.

Precautions and Warnings

• Use cautiously in patients with history of peptic ulcer or GI bleeding
• Long-term use should be medically supervised
• Monitor kidney and liver function during therapy
• Avoid use during late pregnancy
• Use cautiously in patients with cardiovascular disease
• Inform your physician about all medical conditions

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Esona Tablet may interact with:

• Other NSAIDs or corticosteroids (increased GI risk)
• Anticoagulants such as warfarin
• Antihypertensive medications
• Diuretics
• Methotrexate

Always inform your healthcare provider about all medicines being used.

Storage

• Store below 30°C in a cool, dry place
• Protect from light and moisture
• Keep out of reach of children.