Doxerol Injection 4 mcg/2 ml contains Doxercalciferol, a synthetic vitamin D2 analog used to manage secondary hyperparathyroidism in patients with chronic kidney disease (CKD). By controlling elevated parathyroid hormone (PTH) levels, Doxercalciferol helps maintain calcium and phosphorus balance, reducing the risk of renal osteodystrophy and associated bone complications. The injectable form allows precise dosing and rapid therapeutic effect, particularly for patients undergoing hemodialysis or those unable to take oral vitamin D analogs.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Doxercalciferol 4 mcg per 2 ml

Indications

Doxerol Injection is indicated for:

• Secondary hyperparathyroidism in CKD patients
• Prevention and treatment of renal osteodystrophy
• Patients with vitamin D deficiency who require parenteral therapy

Mechanism of Action

Doxercalciferol is converted in the liver to its active form, 1,25-dihydroxyvitamin D2, which:

• Suppresses excessive PTH secretion
• Enhances intestinal calcium and phosphorus absorption
• Supports bone mineralization and reduces skeletal complications in CKD

This targeted mechanism helps manage mineral and bone disorders associated with chronic kidney disease.

Dosage and Administration

• Administered intravenously or intramuscularly under medical supervision
• Dose individualized based on serum PTH, calcium, and phosphorus levels
• Often given 2–3 times weekly, particularly during dialysis sessions
• Regular monitoring of electrolyte levels is required to prevent hypercalcemia or hyperphosphatemia
• Adjust dosage gradually according to patient response

Benefits

• Effectively lowers elevated PTH levels
• Maintains healthy calcium and phosphorus balance
• Prevents bone pain, fractures, and deformities in CKD patients
• Injectable form ensures accurate dosing and rapid action
• Suitable for patients unable to tolerate oral therapy

Side Effects

Common side effects:

• Nausea or mild vomiting
• Headache or dizziness
• Muscle aches

Serious side effects (rare):

• Hypercalcemia (high calcium levels)
• Hyperphosphatemia (high phosphorus levels)
• Cardiac arrhythmias or other electrolyte-related complications

Seek immediate medical care if severe side effects occur.

Precautions

• Monitor calcium, phosphorus, and PTH levels regularly
• Use with caution in patients with hypercalcemia, vitamin D toxicity, or cardiovascular disorders
• Avoid excessive calcium supplementation unless prescribed
• Adjust dose carefully in patients with liver dysfunction

Contraindications

• Hypercalcemia or vitamin D toxicity
• Hypersensitivity to Doxercalciferol or other vitamin D analogs
• Severe hyperphosphatemia

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

• May interact with digoxin, thiazide diuretics, or calcium supplements
• Monitor patients for hypercalcemia
• Inform healthcare providers about all medications being taken

Storage

• Store at 2–8°C
• Protect from light
• Do not freeze
• Keep out of reach of children.