Doriject Injection 500 mg/vial contains Doripenem, a broad-spectrum carbapenem antibiotic used for the treatment of serious bacterial infections. It is highly effective against a wide range of Gram-positive and Gram-negative organisms, including multidrug-resistant strains. Doripenem is typically reserved for severe infections requiring hospitalization and intravenous therapy, ensuring rapid and reliable antibacterial action.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each vial contains:

• Doripenem 500 mg (as sterile powder for injection)

The powder is reconstituted with a suitable diluent before intravenous administration.

Indications

Doriject Injection is indicated for the treatment of:

• Complicated intra-abdominal infections
• Complicated urinary tract infections (including pyelonephritis)
• Hospital-acquired and ventilator-associated pneumonia
• Severe bacterial infections caused by susceptible organisms

It is generally used in hospital settings under close medical supervision.

Pharmacological Action

Doripenem is a carbapenem antibiotic that works by inhibiting bacterial cell wall synthesis:

• Binds to penicillin-binding proteins (PBPs), disrupting cell wall formation
• Leads to bacterial cell lysis and death (bactericidal effect)
• Exhibits stability against many beta-lactamases, including extended-spectrum beta-lactamases (ESBLs)

Its broad-spectrum activity makes it effective against resistant and mixed bacterial infections.

Dosage & Administration

• Administered intravenously (IV) only
• The usual adult dose is 500 mg every 8 hours, infused over 1 hour
• Dosage adjustments may be required in patients with renal impairment
• Treatment duration depends on the type and severity of infection

Administration should be performed by qualified healthcare professionals.

Side Effects

Common and potential side effects include:

• Nausea and vomiting
• Diarrhea
• Headache
• Rash or allergic reactions
• Injection site reactions
• Rarely, seizures (especially in patients with CNS disorders or renal impairment)

Immediate medical attention is required for severe hypersensitivity reactions.

Contraindications

• Known hypersensitivity to Doripenem, carbapenems, or other beta-lactam antibiotics
• History of severe allergic reactions to penicillins or cephalosporins (use with caution)

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions & Warnings

• Use cautiously in patients with renal impairment (dose adjustment required)
• Monitor for signs of allergic reactions
• Prolonged use may lead to superinfection, including fungal infections
• Risk of Clostridioides difficile-associated diarrhea

Use in Pregnancy & Lactation

Doripenem should be used during pregnancy only if clearly needed. Caution is advised during breastfeeding, as it is not known whether the drug passes into breast milk.

Storage

• Store below 25°C
• Protect from light and moisture
• Use reconstituted solution promptly as per guidelines.