Dopair Tablet combines Levodopa 100 mg with Carbidopa 10 mg, a well-established therapy for managing Parkinson’s disease and parkinsonian syndromes. Levodopa is a precursor of dopamine that replenishes dopamine levels in the brain, improving motor function, reducing tremors, rigidity, and bradykinesia. Carbidopa inhibits peripheral metabolism of Levodopa, allowing more of it to reach the brain and reducing side effects such as nausea and vomiting. This combination ensures effective symptom control with enhanced tolerability.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Levodopa 100 mg (dopamine precursor)
• Carbidopa 10 mg (peripheral dopa-decarboxylase inhibitor)

Indications

Dopair Tablet is indicated for:

• Parkinson’s disease (all stages)
• Parkinsonian syndromes caused by dopamine deficiency
• Improvement of motor symptoms such as tremor, rigidity, and bradykinesia

Mechanism of Action

• Levodopa: Crosses the blood-brain barrier and converts to dopamine in the central nervous system, replenishing depleted dopamine levels.
• Carbidopa: Inhibits the peripheral conversion of Levodopa to dopamine, reducing peripheral side effects and increasing the amount of Levodopa that reaches the brain.

Together, they improve motor function while minimizing gastrointestinal and cardiovascular side effects.

Dosage and Administration

• Take orally as prescribed by a healthcare professional
• Typically administered 1–3 times daily, depending on disease severity and patient response
• Tablets can be taken with or after meals to reduce gastrointestinal discomfort
• Do not abruptly stop therapy; dosage adjustments should be guided by a physician

Benefits

• Improves motor function and mobility in Parkinson’s disease
• Reduces tremors, rigidity, and slowness of movement
• Carbidopa reduces nausea and other peripheral side effects
• Enhances quality of life for patients with dopamine deficiency
• Convenient oral tablet formulation

Side Effects

Common side effects:

• Nausea and vomiting
• Dizziness or lightheadedness
• Dyskinesia (involuntary movements)
• Orthostatic hypotension

Rare side effects:

• Hallucinations or confusion
• Cardiac arrhythmias
• Severe allergic reactions

Seek medical attention for severe or persistent side effects.

Precautions

• Monitor blood pressure regularly, especially in elderly patients
• Use with caution in patients with heart disease, psychiatric disorders, or liver/kidney impairment
• Avoid abrupt discontinuation to prevent worsening of symptoms
• Inform your doctor about other medications being taken, including MAO inhibitors and antihypertensives

Contraindications

• Hypersensitivity to Levodopa, Carbidopa, or any component of the formulation
• Narrow-angle glaucoma
• History of melanoma or suspicious skin lesions
• Concurrent use of non-selective MAO inhibitors

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

• May interact with MAO inhibitors, antipsychotics, antihypertensives, and iron supplements
• Inform your healthcare provider of all medications currently being taken

Storage

• Store in a cool, dry place below 30°C
• Protect from light and moisture
• Keep out of reach of children.