Doltro Injection 60 mg/2 ml contains Ketorolac Tromethamine 60 mg, a potent non-steroidal anti-inflammatory drug (NSAID) indicated for the short-term management of moderate to severe pain. Administered parenterally, this formulation provides rapid onset of analgesia, making it ideal for postoperative pain, musculoskeletal injuries, renal colic, or other acute pain conditions where immediate relief is needed.

Ketorolac is highly effective in reducing pain and inflammation by inhibiting the production of prostaglandins, the chemical mediators responsible for pain, swelling, and fever. Unlike opioid analgesics, Doltro Injection does not cause significant sedation or dependence, making it a safe and effective option for short-term pain management under medical supervision.

This injection is particularly useful for patients unable to take oral medication, those requiring rapid pain relief, or in clinical settings such as hospitals, emergency departments, and post-surgical recovery units.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Doltro Injection 60 mg/2 ml is indicated for:

• Postoperative pain management, including after orthopedic or dental surgery

• Acute musculoskeletal pain, such as sprains, strains, or back pain

• Pain associated with renal colic

• Short-term therapy for moderate to severe acute pain where oral administration is not feasible

Key Benefits

• Provides rapid onset of pain relief through parenteral administration

• Reduces pain, inflammation, and swelling associated with acute conditions

• Non-opioid therapy, minimizing risk of dependence

• Suitable for patients unable to take oral NSAIDs

• Effective for short-term management in hospital or clinical settings

Mechanism of Action

Ketorolac Tromethamine is a non-selective inhibitor of cyclooxygenase (COX-1 and COX-2). COX enzymes catalyze the production of prostaglandins, which are responsible for pain, inflammation, and fever.

• Analgesic effect: Reduces pain by inhibiting prostaglandin-mediated stimulation of nociceptive nerve endings.

• Anti-inflammatory effect: Decreases inflammation and swelling by reducing prostaglandin-induced vasodilation and fluid accumulation.

• Antipyretic effect: Helps in lowering fever by modulating hypothalamic prostaglandin activity.

By targeting these pathways, Doltro Injection provides rapid and effective relief from moderate to severe pain in a short period of time.

Dosage and Administration

• The usual adult dose is 60 mg (2 ml) intramuscularly (IM) or intravenously (IV) as a single dose.

• The maximum recommended daily dose is 120 mg (given as 60 mg every 6 hours) for short-term use, not exceeding 5 days.

• Administer IV slowly over 15–30 seconds to reduce the risk of local irritation or adverse reactions.

• For IM injection, inject into a large muscle mass (e.g., gluteal or thigh muscle).

• Monitor patients for adverse effects, particularly those with renal, hepatic, or cardiovascular conditions.

Precautions

• Not recommended for patients with active gastrointestinal bleeding, peptic ulcer disease, severe renal impairment, or known hypersensitivity to NSAIDs.

• Avoid concomitant use with other NSAIDs, anticoagulants, or corticosteroids unless prescribed.

• Use cautiously in elderly patients and those with cardiovascular disease.

• Not advised during late pregnancy due to potential fetal risks.

• Monitor for signs of gastrointestinal bleeding, kidney dysfunction, or allergic reactions during therapy.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Doltro Injection 60 mg/2 ml is generally well tolerated. Common side effects may include:

• Injection site pain or irritation

• Gastrointestinal discomfort, nausea, or heartburn

• Dizziness or headache

• Rarely, gastrointestinal bleeding, renal dysfunction, or allergic reactions

Most side effects are mild and transient, resolving after discontinuation or dose adjustment.

Storage

Store below 30°C in a cool, dry place, protected from light and moisture. Keep out of reach of children. Use single-use vials only once and discard any unused solution.