Diplin M Tablet 2.5 mg+850 mg is a fixed-dose combination of Linagliptin and Metformin Hydrochloride used for the management of type 2 diabetes mellitus. It helps improve blood glucose control through dual mechanisms—enhancing insulin secretion and reducing hepatic glucose production. This combination is used along with diet and exercise to achieve better long-term glycemic control.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Diplin M Tablet is indicated for:

• Type 2 diabetes mellitus in adults
• Patients inadequately controlled on monotherapy (Linagliptin or Metformin alone)
• Improvement of fasting and postprandial blood glucose levels
• Long-term glycemic management as part of a comprehensive diabetes plan

Mechanism of Action

Diplin M Tablet works through complementary actions of its two components:

Linagliptin:

• Inhibits DPP-4 enzyme
• Increases incretin hormones (GLP-1 and GIP)
• Enhances glucose-dependent insulin secretion
• Reduces glucagon secretion

Metformin Hydrochloride:

• Decreases hepatic glucose production
• Improves peripheral insulin sensitivity
• Reduces intestinal absorption of glucose

Together, they provide effective and balanced blood sugar control.

Dosage and Administration

• Dosage should be determined by a physician based on patient needs
• Usually taken once or twice daily with meals to reduce gastrointestinal side effects
• Swallow the tablet whole with water
• Do not crush or chew
• Regular monitoring of blood glucose is recommended

Benefits

• Dual-action control of blood sugar levels
• Effective reduction of both fasting and post-meal glucose
• Lower risk of hypoglycemia compared to insulin-based regimens
• Convenient fixed-dose combination improves compliance
• Supports long-term diabetes management

Possible Side Effects

Common side effects may include:

• Nausea
• Diarrhea
• Abdominal discomfort
• Headache
• Loss of appetite

Less common but serious side effects:

• Lactic acidosis (rare but serious with metformin)
• Pancreatitis
• Vitamin B12 deficiency with long-term use

Seek immediate medical attention if severe symptoms occur.

Precautions and Warnings

• Not recommended for type 1 diabetes or diabetic ketoacidosis
• Use cautiously in patients with kidney or liver impairment
• Monitor renal function regularly during therapy
• Avoid excessive alcohol intake due to risk of lactic acidosis
• Use during pregnancy or breastfeeding only under medical supervision

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Diplin M Tablet may interact with:

• Alcohol (increases risk of lactic acidosis)
• Iodinated contrast agents
• Other antidiabetic drugs (may increase hypoglycemia risk)
• Rifampicin (may reduce linagliptin effectiveness)

Always inform your healthcare provider about all medications being used.

Storage

• Store below 30°C in a dry place
• Protect from light and moisture
• Keep out of reach of children.