Dilup Tablet combines Furosemide 40 mg and Spironolactone 50 mg in a single formulation, offering a synergistic approach to diuretic therapy. This combination is used to manage fluid retention (edema) associated with conditions such as heart failure, liver cirrhosis, and kidney disorders. Furosemide, a loop diuretic, promotes rapid excretion of excess water and sodium, while Spironolactone, a potassium-sparing diuretic, helps maintain potassium balance, reducing the risk of hypokalemia. Together, they provide effective fluid control with improved safety for electrolyte balance.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Furosemide 40 mg (loop diuretic)
• Spironolactone 50 mg (potassium-sparing diuretic)

Indications

Dilup Tablet is indicated for:

• Edema associated with heart failure
• Edema due to liver cirrhosis or nephrotic syndrome
• Hypertension management where dual diuretic therapy is needed
• Prevention of hypokalemia during long-term diuretic therapy

Mechanism of Action

• Furosemide: Acts on the ascending loop of Henle in the kidney to inhibit sodium, chloride, and water reabsorption, producing potent diuresis and reducing fluid overload.
• Spironolactone: Antagonizes aldosterone in the distal renal tubules, promoting sodium and water excretion while conserving potassium and hydrogen ions.

The combination ensures effective diuresis while minimizing the risk of electrolyte imbalance, particularly potassium loss.

Dosage and Administration

• Take orally as prescribed by a healthcare professional
• Usually administered once daily or as directed, depending on the patient’s condition
• Take with or after meals to reduce gastrointestinal discomfort
• Regular monitoring of kidney function, electrolytes, and blood pressure is recommended

Benefits

• Effective dual-action diuretic therapy for fluid retention
• Helps maintain potassium balance and reduce hypokalemia risk
• Supports better management of edema in heart, liver, and kidney disorders
• May assist in blood pressure control in hypertensive patients
• Convenient combination reduces pill burden and improves adherence

Side Effects

Common side effects:

• Increased urination
• Dizziness or lightheadedness
• Gastrointestinal disturbances (nausea, vomiting)
• Electrolyte imbalances (e.g., hyperkalemia or hyponatremia)

Rare side effects:

• Severe allergic reactions
• Gynecomastia or hormonal effects from spironolactone
• Kidney function impairment

Precautions

• Monitor blood pressure, electrolytes, and kidney function regularly
• Avoid excessive salt intake while on therapy
• Use cautiously in patients with kidney or liver impairment
• May interact with ACE inhibitors, ARBs, NSAIDs, and other medications affecting electrolytes

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

• Known hypersensitivity to Furosemide or Spironolactone
• Severe kidney or liver disease with anuria
• Hyperkalemia or Addison’s disease
• Pregnancy or breastfeeding without medical supervision

Storage

• Store in a cool, dry place below 30°C
• Protect from moisture and direct sunlight
• Keep out of reach of children.